Cyclo(-Gly-His) (CAS 15266-88-3)

Cyclo(-Gly-His), also known as cyclo(glycylhistidyl), is a dipeptide that is cyclic in nature and is of particular interest in biochemistry and peptide research. This compound is studied for its role as a model in understanding peptide bond conformation and stability due to its cyclic structure, which restricts the freedom of rotation around the peptide bond. Researchers utilize Cyclo(-Gly-His) to explore the mechanisms of peptide self-assembly and aggregation, processes that are fundamental to the formation of amyloid fibrils and other protein aggregates. The histidine residue in Cyclo(-Gly-His) is also the subject of research focusing on metal ion binding and the compound′s potential ability to chelate metal ions, which is relevant in the study of metalloenzymes and metal-related diseases. Additionally, Cyclo(-Gly-His) is used as a scaffold for the synthesis of more complex cyclic peptides and peptidomimetics, contributing to the understanding of peptide structure-function relationships.