cyclin K Antibody (R-17): sc-81842
- cyclin K Antibody (R-17) is a mouse monoclonal IgG1 κ provided at 100 µg/ml
- raised against recombinant cyclin K of human origin
- recommended for detection of cyclin K of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for cyclin K Antibody (R-17). This work is in progress.
Cyclin K Antibody (R-17) is a mouse monoclonal IgG1 antibody that detects cyclin K in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Cyclin K is a vital component of the positive transcription elongation factor β (P-TEFβ) complex, which plays a significant role in the regulation of RNA polymerase II (RNAPII) transcription elongation. By phosphorylating the carboxyl-terminal domain of the largest RNAPII subunit, cyclin K facilitates the transition from transcription initiation to elongation, thereby ensuring efficient gene expression. This process is crucial for proper cellular function and development, as cyclin K influences the expression of genes necessary for various biological processes. Cyclin K is widely expressed across adult mouse and human tissues, with particularly high levels found in the developing germ cells of the testis and ovaries, highlighting cyclin K′s importance in reproductive biology. The cyclin K gene encodes a 357 amino acid protein located on human chromosome 14q32, and cyclin K′s interactions with other proteins in the P-TEFβ complex, such as cyclin dependent kinase 9 (Cdk9), underscore cyclin K′s essential role in transcriptional regulation. Anti-cyclin K antibody (R-17) is an invaluable tool for researchers studying transcriptional control and its implications in various physiological and pathological contexts.
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cyclin K Antibody (R-17) References:
- Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation. | Lei, T., et al. 2018. Nat Commun. 9: 1876. PMID: 29760377
- The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. | Słabicki, M., et al. 2020. Nature. 585: 293-297. PMID: 32494016
- Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation. | Lv, L., et al. 2020. Elife. 9: PMID: 32804079
- Cyclin K interacts with β-catenin to induce Cyclin D1 expression and facilitates tumorigenesis and radioresistance in lung cancer. | Yao, G., et al. 2020. Theranostics. 10: 11144-11158. PMID: 33042275
- 3,5,7-Substituted Pyrazolo[4,3-d]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders. | Jorda, R., et al. 2022. J Med Chem. 65: 8881-8896. PMID: 35749742
- CYCLIN K down-regulation induces androgen receptor gene intronic polyadenylation, variant expression and PARP inhibitor vulnerability in castration-resistant prostate cancer. | Sun, R., et al. 2022. Proc Natl Acad Sci U S A. 119: e2205509119. PMID: 36129942
- Novel quinazolin-4(3H)-one based Cyclin K degraders regulate alternative polyadenylation activity. | Sano, O., et al. 2023. Biochem Biophys Res Commun. 676: 6-12. PMID: 37480690
- The reversible inhibitor SR-4835 binds Cdk12/cyclin K in a noncanonical G-loop conformation. | Schmitz, M., et al. 2024. J Biol Chem. 300: 105501. PMID: 38016516
- The CDK12 inhibitor SR-4835 functions as a molecular glue that promotes cyclin K degradation in melanoma. | Houles, T., et al. 2023. Cell Death Discov. 9: 459. PMID: 38104154
- Discovery and design of molecular glue enhancers of CDK12-DDB1 interactions for targeted degradation of cyclin K. | Ghosh, P., et al. 2024. RSC Chem Biol. 6: 36-55. PMID: 39450271
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cyclin K Antibody (R-17) | sc-81842 | 100 µg/ml | $333.00 |