cyclin G2 Antibody (1F9-C11): sc-293302

Cyclin G2 Antibody (1F9-C11) is a mouse monoclonal IgG2b kappa light chain antibody that detects cyclin G2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-cyclin G2 antibody (1F9-C11) is available as a non-conjugated format. Cyclins, including cyclin G2, are essential regulatory subunits of cyclin-dependent kinases (Cdks), which control cell cycle progression. Cyclin G2 (1F9-C11) monoclonal antibody recognizes a protein crucial for regulating G2 to M phase transition, a critical checkpoint ensuring proper cell division. Cyclin G2 features a typical N-terminal cyclin box and a C-terminal domain homologous to the tyrosine phosphorylation site of the epidermal growth factor receptor, suggesting involvement in signaling pathways that influence cell growth and division. Anti-cyclin G2 antibody (1F9-C11) detects a protein that rapidly induces within three hours following growth stimulation and remains elevated, indicating potential roles in responding to cellular signals. Cyclin G2 shares 53% amino acid sequence identity with cyclin G1, but peak expression occurs in late S phase, contrasting with cyclin G1′s constitutive expression. This differential expression pattern highlights unique regulatory mechanisms in cell cycle control, making cyclin G2 a significant target for research in cell biology and cancer studies.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

cyclin G2 Antibody (1F9-C11) References:

1. D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA.  |  Xiong, Y., et al. 1992. Cell. 71: 505-14. PMID: 1358458
2. Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins.  |  Matsushime, H., et al. 1992. Cell. 71: 323-34. PMID: 1423597
3. Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes.  |  Fang, F. and Newport, JW. 1991. Cell. 66: 731-42. PMID: 1652371
4. Cyclin G2 is a centrosome-associated nucleocytoplasmic shuttling protein that influences microtubule stability and induces a p53-dependent cell cycle arrest.  |  Arachchige Don, AS., et al. 2006. Exp Cell Res. 312: 4181-204. PMID: 17123511
5. Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family.  |  Koff, A., et al. 1991. Cell. 66: 1217-28. PMID: 1833068
6. Cyclin A is required for the onset of DNA replication in mammalian fibroblasts.  |  Girard, F., et al. 1991. Cell. 67: 1169-79. PMID: 1836977
7. Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B.  |  Pines, J. and Hunter, T. 1990. Nature. 346: 760-3. PMID: 2143810
8. Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1.  |  Tamura, K., et al. 1993. Oncogene. 8: 2113-8. PMID: 8336937
9. Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression.  |  Horne, MC., et al. 1996. J Biol Chem. 271: 6050-61. PMID: 8626390

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-cyclin G2 Antibody (1F9-C11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-cyclin G2 Antibody (1F9-C11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

cyclin G2 Antibody (1F9-C11) Specifications

Alternate Product Name: cyclin G2

Product Clone Name: 1F9-C11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-344

Epitope Target: cyclin G2

Epitope Species: human

Product Reactivity/Detection: cyclin G2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for cyclin G2 Antibody (1F9-C11): N/A