Molecular structure of Cyclic Pifithrin-α hydrobromide, CAS Number: 511296-88-1
Cyclic Pifithrin-α hydrobromide (CAS 511296-88-1)
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Alternate Names:
2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole, HBr
Application:
Cyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α
CAS Number:
511296-88-1
Purity:
≥95%
Molecular Weight:
349.29
Molecular Formula:
C16H16N2S•HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-alpha a small molecule inhibitor of p53. It reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis, with less cytotoxicity than the parent compound. Potent STAT6 transcriptional inhibitor. This compound may act to prevent dexamethasone-induced cell death in murine thymocytes with an EC50value of 2.01muM. Sensitizes p53-deficient tumors to radiotherapy and chemotherapy increases apoptosis in target cells when used in combination with antimicrotubule agents.
Cyclic Pifithrin-α hydrobromide (CAS 511296-88-1) References
- Use of pifithrin to inhibit p53-mediated signalling of TNF in dystrophic muscles of mdx mice. | Waters, FJ., et al. 2010. Mol Cell Biochem. 337: 119-31. PMID: 19859789
- Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. | Christodoulou, MS., et al. 2011. Bioorg Med Chem. 19: 1649-57. PMID: 21324703
- Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β. | Fernández-Cruz, ML., et al. 2011. Life Sci. 88: 774-83. PMID: 21362431
- p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells. | Da Pozzo, E., et al. 2014. ACS Chem Neurosci. 5: 390-9. PMID: 24646317
- Sirt1 Regulates p53 Stability and Expression of Its Target S100B during Long-Term Potentiation in Rat Hippocampus. | Lisachev, PD., et al. 2016. Bull Exp Biol Med. 160: 432-4. PMID: 26902357
Inhibitor of:
p53.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cyclic Pifithrin-α hydrobromide, 10 mg | sc-361164 | 10 mg | $231.00 | |||
Cyclic Pifithrin-α hydrobromide, 50 mg | sc-361164A | 50 mg | $938.00 |