Molecular structure of CX546, CAS Number: 215923-54-9
CX546 (CAS 215923-54-9)
Alternate Names:
(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone
Application:
CX546 is an AMPA receptor potentiator and GluR activator
CAS Number:
215923-54-9
Molecular Weight:
247.29
Molecular Formula:
C14H17NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
AMPA receptor potentiator which is specifically bound to agonist bound non-desensitized receptors.
CX546 (CAS 215923-54-9) References
- Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546. | Nagarajan, N., et al. 2001. Neuropharmacology. 41: 650-63. PMID: 11640919
- Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action. | Arai, AC., et al. 2002. J Pharmacol Exp Ther. 303: 1075-85. PMID: 12438530
- Identification of a site in GluR1 and GluR2 that is important for modulation of deactivation and desensitization. | Leever, JD., et al. 2003. Mol Pharmacol. 64: 5-10. PMID: 12815155
- Modulation of AMPA receptor kinetics differentially influences synaptic plasticity in the hippocampus. | Arai, AC., et al. 2004. Neuroscience. 123: 1011-24. PMID: 14751292
- AMPA receptor potentiators for the treatment of CNS disorders. | O'Neill, MJ., et al. 2004. Curr Drug Targets CNS Neurol Disord. 3: 181-94. PMID: 15180479
- Ampakine CX546 bolsters energetic response of astrocytes: a novel target for cognitive-enhancing drugs acting as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators. | Pellerin, L. and Magistretti, PJ. 2005. J Neurochem. 92: 668-77. PMID: 15659236
- The ampakine CX546 restores the prepulse inhibition and latent inhibition deficits in mGluR5-deficient mice. | Lipina, T., et al. 2007. Neuropsychopharmacology. 32: 745-56. PMID: 16936708
- Ampakines alleviate respiratory depression in rats. | Ren, J., et al. 2006. Am J Respir Crit Care Med. 174: 1384-91. PMID: 16973981
- Blockade of the metabotropic glutamate 2/3 receptors enhances social memory via the AMPA receptor in rats. | Shimazaki, T., et al. 2007. Eur J Pharmacol. 575: 94-7. PMID: 17727837
- Modulation of agonist binding to AMPA receptors by 1-(1,4-benzodioxan-6-ylcarbonyl)piperidine (CX546): differential effects across brain regions and GluA1-4/transmembrane AMPA receptor regulatory protein combinations. | Montgomery, KE., et al. 2009. J Pharmacol Exp Ther. 331: 965-74. PMID: 19717789
- Effects of agents targeting glutamatergic systems on marble-burying behavior. | Iijima, M., et al. 2010. Neurosci Lett. 471: 63-5. PMID: 20036313
- Ampakine CX546 increases proliferation and neuronal differentiation in subventricular zone stem/progenitor cell cultures. | Schitine, C., et al. 2012. Eur J Neurosci. 35: 1672-83. PMID: 22506985
- Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex. | Zhou, W., et al. 2014. Eur Psychiatry. 29: 419-23. PMID: 24321772
- AMPAkines have novel analgesic properties in rat models of persistent neuropathic and inflammatory pain. | Le, AM., et al. 2014. Anesthesiology. 121: 1080-90. PMID: 25338127
- Enhanced AMPA receptor function promotes cerebellar long-term depression rather than potentiation. | van Beugen, BJ., et al. 2014. Learn Mem. 21: 662-7. PMID: 25403454
Activator of:
GluR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CX546, 10 mg | sc-205278 | 10 mg | $194.00 | |||
CX546, 50 mg | sc-205278A | 50 mg | $666.00 |