Molecular structure of CV-6209, CAS Number: 100488-87-7
CV-6209 (CAS 100488-87-7)
See product citations (9)
Alternate Names:
CV-6209 is also known as CV-6209 chloride.
Application:
CV-6209 is a competitive Platelet Activating Factor receptor antagonist that inhibits PAF induced human platelet aggregation.
CAS Number:
100488-87-7
Purity:
≥95%
Molecular Weight:
642.31
Molecular Formula:
C34H60N3O6•Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CV-6209 is a competitive platelet activating factor (PAF) receptor antagonist. CV-6209 inhibits PAF induced human platelet aggregation and PAF induced hypotension and lethality. Studies found aggregation of rabbit and human platelets induced by PAF with IC50 values of 75 and 170 nM was inhibited by CV-6209. CV-6209 is used in vivo and in vitro to study the role of PAF receptor signaling. CV-6209 is also known as CV-6209 chloride, 2-(2-Acetyl-6-methoxy-3,9-dioxo-4,8-dioxa-2,10-diazaoctacos-1-yl)-1-ethyl-pyridinium Chloride, and 2-[N-Acetyl-N-(2-methoxy-3-octadecylcarbamoyloxypropoxycarbonyl)aminomethyl]-1-ethylpyridinium Chloride.
CV-6209 (CAS 100488-87-7) References
- Effects of a platelet-activating factor antagonist, CV-6209, on gastric mucosal lesions induced by ischemia-reperfusion. | Yoshikawa, T., et al. 1992. Lipids. 27: 1058-60. PMID: 1487954
- Inhibition of neutrophil respiratory burst and degranulation responses to platelet-activating factor by antagonists WEB 2086, CV 6209 and CV 3988. | Bates, EJ., et al. 1992. Int Arch Allergy Immunol. 97: 50-6. PMID: 1582698
- Effects of the platelet-activating factor antagonists CV-6209 and CV-3988 on nephrotoxic serum nephritis in the rat. | Iida, H., et al. 1992. Nephron. 60: 471-6. PMID: 1584324
- Comparative study of the effect of CV-6209, a specific PAF-antagonist, on rat paw edema caused by different phlogogen agents. | Merlos, M., et al. 1990. Pharmacology. 40: 211-7. PMID: 1697076
- The effect of CV-3988 and CV-6209 on the acute gastric erosions of rats due to water-immersion and restraint stress. | Nogami, M., et al. 1991. Lipids. 26: 1354-5. PMID: 1819732
- Effects of the PAF-analog and -antagonist CV-6209 on cultured human glioma cell lines. | Gáti, I., et al. 1991. Prostaglandins Leukot Essent Fatty Acids. 43: 103-10. PMID: 1886907
- Pregnancy suppression by a structurally related antagonist for platelet activating factor, CV-6209, in mice. | Ando, M., et al. 1990. Asia Oceania J Obstet Gynaecol. 16: 283-90. PMID: 2088253
- Anti-Helicobacter pylori actions of CV-6209, a platelet-activating factor receptor antagonist. | Iwao, Y., et al. 2013. J Gen Appl Microbiol. 59: 147-52. PMID: 23759868
- CV 6209 is a non-competitive antagonist of platelet-activating factor receptors on guinea-pig resident peritoneal macrophages. | Stewart, AG. 1989. Clin Exp Pharmacol Physiol. 16: 813-20. PMID: 2558827
- Salutary consequences of blockade of platelet activating factor in hemorrhagic shock. | Stahl, GL., et al. 1988. Eur J Pharmacol. 149: 233-40. PMID: 3409951
- CV-6209, a highly potent antagonist of platelet activating factor in vitro and in vivo. | Terashita, Z., et al. 1987. J Pharmacol Exp Ther. 242: 263-8. PMID: 3612533
- Platelet-activating-factor-induced changes in cardiovascular function and oxyradical status of myocardium in presence of the PAF antagonist CV-6209. | Gupta, JB., et al. 1994. Angiology. 45: 25-36. PMID: 8285381
- Drug susceptibility of PCA in WBB6F1-W/Wv mice. | Kimura, S., et al. 1998. Cell Mol Life Sci. 54: 456-60. PMID: 9645225
Inhibitor of:
PAF-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CV-6209, 2.5 mg | sc-207461 | 2.5 mg | $612.00 | |||
CV-6209, 5 mg | sc-207461A | 5 mg | $1112.00 | |||
CV-6209, 10 mg | sc-207461B | 10 mg | $2346.00 |