Molecular structure of Curcumin-d6, CAS Number: 1246833-26-0
Curcumin-d6 (CAS 1246833-26-0)
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Alternate Names:
(E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione-d6; C Yellow 15-d6
CAS Number:
1246833-26-0
Molecular Weight:
374.42
Molecular Formula:
C21H14D6O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Curcumin-d6 is a deuterated form of curcumin, a natural compound derived from turmeric. Deuteration involves the substitution of hydrogen atoms with deuterium atoms, resulting in the formation of this modified version. Curcumin-d6 is a potent phenolic compound known for its anti-tumor properties, as well as its anti-inflammatory and antioxidant effects. It induces apoptosis in cancer cells, inhibits protein kinase C (PKC) activity triggered by phorbol ester, and reduces the production of inflammatory cytokines in peripheral blood monocytes and alveolar macrophages. It is a powerful inhibitor of EGFR tyrosine kinase and IκB kinase, and it also suppresses the activity of inducible nitric oxide synthase (iNOS), cyclooxygenase, and lipoxygenase.
Curcumin-d6 (CAS 1246833-26-0) References
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- Distribution of Curcumin and THC in Peripheral Blood Mononuclear Cells Isolated from Healthy Individuals and Patients with Chronic Lymphocytic Leukemia. | Bolger, GT., et al. 2018. Anticancer Res. 38: 121-130. PMID: 29277764
- A Novel Triple Stage Ion Trap MS method validated for curcumin pharmacokinetics application: A comparison summary of the latest validated curcumin LC/MS methods. | Li, W., et al. 2018. J Pharm Biomed Anal. 156: 116-124. PMID: 29702389
- Administering Fixed Oral Doses of Curcumin to Rats through Voluntary Consumption. | Hocking, AJ., et al. 2018. J Am Assoc Lab Anim Sci. 57: 508-512. PMID: 30157991
- Pharmacokinetics, Pharmacodynamics, and PKPD Modeling of Curcumin in Regulating Antioxidant and Epigenetic Gene Expression in Healthy Human Volunteers. | Cheng, D., et al. 2019. Mol Pharm. 16: 1881-1889. PMID: 30860383
- Pharmacokinetics and pharmacodynamics of three oral formulations of curcumin in rats. | Wang, L., et al. 2020. J Pharmacokinet Pharmacodyn. 47: 131-144. PMID: 32020381
- The enhanced bioavailability of free curcumin and bioactive-metabolite tetrahydrocurcumin from a dispersible, oleoresin-based turmeric formulation. | Panda, SK., et al. 2021. Medicine (Baltimore). 100: e26601. PMID: 34232211
- Neuroprotective Activities of Curcumin in Parkinson's Disease: A Review of the Literature. | Nebrisi, EE. 2021. Int J Mol Sci. 22: PMID: 34681908
- Superior Bioavailability of a Novel Curcumin Formulation in Healthy Humans Under Fasting Conditions. | Kothaplly, S., et al. 2022. Adv Ther. 39: 2128-2138. PMID: 35294738
- Formulated Curcumin Prevents Paclitaxel-Induced Peripheral Neuropathy through Reduction in Neuroinflammation by Modulation of α7 Nicotinic Acetylcholine Receptors. | Caillaud, M., et al. 2022. Pharmaceutics. 14: PMID: 35745868
- Bis-iodine-labeled Curcumin as a Potential CT Imaging Agent for β-amyloid Plaques in the Brain. | Dai, Y., et al. 2022. CNS Neurol Disord Drug Targets.. PMID: 35796449
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Curcumin-d6, 5 mg | sc-460977 | 5 mg | $388.00 | |||
Curcumin-d6, 50 mg | sc-460977A | 50 mg | $2387.00 |