Date published: 2026-4-30

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Curcumin (CAS 458-37-7)

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Alternate Names:
Curcumin is also known as Diferuloylmethane.
Application:
Curcumin is a yellow-orange dye, NOS2 regulator, and inhibitor of NF-κB, 5-LO, Cox-2, COP9, and p300/CBP.
CAS Number:
458-37-7
Purity:
≥95%
Molecular Weight:
368.38
Molecular Formula:
C21H20O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Curcumin is a yellow-orange dye obtained from tumeric, the powdered root of Curcuma longa that is employed in the preparation of curcuma paper, the detection of boron, and possesses a vast number of biological targets. It may act to inhibit NF-κB, possibly through inhibition of JNK (IC50=10 μM). Curcumin blocks amyloid peptide induced expression of: TNF-α, IL-1β, MCP-1, IL-8, and CCR5, regulates NOS2, inhibits IgE and Ag-induced degranulation of mast cells, inhibits 5-LO (5-lipoxygenase) (IC50=8 μM), Cox-2 (cyclooxygenase-2) (IC50=52 μM), the COP9 signalosome kinase (IC50=10 µM), and p300/CBP. This wide range of activities makes Curcumin an extremely useful tool for developing novel analogues and uses.


Curcumin (CAS 458-37-7) References

  1. A review on antibacterial, antiviral, and antifungal activity of curcumin.  |  Moghadamtousi, SZ., et al. 2014. Biomed Res Int. 2014: 186864. PMID: 24877064
  2. A Review of Curcumin and Its Derivatives as Anticancer Agents.  |  Tomeh, MA., et al. 2019. Int J Mol Sci. 20: PMID: 30818786
  3. Antitumor Activity of Curcumin in Glioblastoma.  |  Walker, BC. and Mittal, S. 2020. Int J Mol Sci. 21: PMID: 33322413
  4. Curcumin and Its Potential Impact on Microbiota.  |  Jabczyk, M., et al. 2021. Nutrients. 13: PMID: 34200819
  5. Inhibition of 5-hydroxy-eicosatetraenoic acid (5-HETE) formation in intact human neutrophils by naturally-occurring diarylheptanoids: inhibitory activities of curcuminoids and yakuchinones.  |  Flynn, DL., et al. 1986. Prostaglandins Leukot Med. 22: 357-60. PMID: 3460103
  6. Inhibition of human neutrophil 5-lipoxygenase activity by gingerdione, shogaol, capsaicin and related pungent compounds.  |  Flynn, DL., et al. 1986. Prostaglandins Leukot Med. 24: 195-8. PMID: 3467378
  7. Inhibition of tumor necrosis factor by curcumin, a phytochemical.  |  Chan, MM. 1995. Biochem Pharmacol. 49: 1551-6. PMID: 7786295
  8. Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines.  |  Jiang, MC., et al. 1996. Nutr Cancer. 26: 111-20. PMID: 8844727
  9. Curcumin inhibits the proliferation and cell cycle progression of human umbilical vein endothelial cell.  |  Singh, AK., et al. 1996. Cancer Lett. 107: 109-15. PMID: 8913274
  10. Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells.  |  Kuo, ML., et al. 1996. Biochim Biophys Acta. 1317: 95-100. PMID: 8950193
  11. Induction of the differentiation of HL-60 promyelocytic leukemia cells by curcumin in combination with low levels of vitamin D3.  |  Sokoloski, JA., et al. 1997. Oncol Res. 9: 31-9. PMID: 9112258
  12. Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappaB activation.  |  Kumar, A., et al. 1998. Biochem Pharmacol. 55: 775-83. PMID: 9586949
  13. Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin.  |  Chen, YR. and Tan, TH. 1998. Oncogene. 17: 173-8. PMID: 9674701

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Curcumin, 1 g

sc-200509
1 g
$37.00

Curcumin, 5 g

sc-200509A
5 g
$69.00

Curcumin, 25 g

sc-200509B
25 g
$109.00

Curcumin, 100 g

sc-200509C
100 g
$218.00

Curcumin, 250 g

sc-200509D
250 g
$239.00

Curcumin, 1 kg

sc-200509F
1 kg
$879.00

Curcumin, 2.5 kg

sc-200509E
2.5 kg
$1968.00

Is it soluble in etoh or not? Cause in technical features there is written "insoluble in ethanol" while in analysis features ther is written "Clear to hazy yellow to orange solution (10 mg/mL in Ethanol)". It's a bit confusing

Asked by: Camilla
Thank you for your question. This compound has low solubility in ethanol. It can be dissolved at up to 25 mg/ml in DMSO or chloroform.
Answered by: Tech Support Europe
Date published: 2024-09-17

Hi. In a previous answer you wrote that the product is soluble in the ethanol, whereas in the technical infos the product is described as not soluble in ethanol. Could you please clarify? Thank you in advance

Asked by: Fran
Thank you for your question. Curcumin is soluble in most organic solvents, but not in ethyl alcohol.
Answered by: Tech Support Europe
Date published: 2023-12-06

Can we dissolve curcumin in PBS (Phosphate buffered saline) for oral (gavage) administration to mice? If yes, please provide a reference. Thanks!

Asked by: Ayeisha
Unfortunately we are not able to provide that information. Our compounds are not pharmaceutical grade and not manufactured under GMP guidelines. Please consult your principal investigator and your animal care and use committee (ACUC) regarding the use of our compounds.
Answered by: Technical Support
Date published: 2018-12-17

Would it be soluble in a buffer? In this case, my buffer would constitute of HEPES, KCl, Glycerol, DTT, BSA and Triton X-100.

Asked by: nabn
Thank you for your question. Curcumin is soluble in ethanol (10 mg/ml), DMSO (25 mg/ml), acetic acid, 0.1M NaOH, 10mM Na2CO3, acetone, water (< 0.1 mg/ml), and chloroform.
Answered by: Technical Support
Date published: 2023-11-20

Curcumin dissolved in DMSO as stock solution (20 mg/mL). But once we dilute it in 1:100 in RPMI 1640 medium for measuring MIC of fungi, it formed precipitate at the well bottom of 96-well plate. Do we have any solution for this?

Asked by: Jasper
Thank you for your question. This product is not provided in a ready for cell culture format, and we recommend filtering before use to ensure that it is appropriate for cell culture applications. Please contact Technical Service by phone, (800)-457-3801 option 2, email <scbt@scbt.com>, or by live chat directly on our website, www.scbt.com if you have any further questions.
Answered by: Technical Service
Date published: 2024-03-08

What is the recommended storage temperature? How should this be stored when dissolved?

Asked by: chemicalsmg
Thank you for your question. The compound, sc-200509, should be stored at room temperature. Once dissolved, the solution should remain stable for approximately 3 months if stored at -20ºC. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2023-02-12
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Rated 4 out of 5 by from I will rate this product a 4 and rate 5I will rate this product a 4 and rate 5 for your logistics, customer service and support.
Date published: 2015-04-20
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Curcumin is rated 4.0 out of 5 by 1.
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