Molecular structure of CUR 61414, CAS Number: 334998-36-6
CUR 61414 (CAS 334998-36-6)
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Alternate Names:
N-[(3S,5S)-1-(1,3-Benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethylbutanamide
Application:
CUR 61414 is a mediator of hedgehog signaling pathways
CAS Number:
334998-36-6
Molecular Weight:
550.69
Molecular Formula:
C31H42N4O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A proline derivative used as a mediator of hedgehog signaling pathways for pharmaceutical and cosmetic uses.
CUR 61414 (CAS 334998-36-6) References
- Hedgehog signaling pathway as a target for therapeutic intervention in basal cell carcinoma. | Williams, JA. 2003. Drug News Perspect. 16: 657-62. PMID: 14747845
- Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis. | Athar, M., et al. 2004. Cancer Res. 64: 7545-52. PMID: 15492281
- Targeting the hedgehog signaling pathway with small molecules. | Kiselyov, AS. 2006. Anticancer Agents Med Chem. 6: 445-9. PMID: 17017853
- Small-molecule modulators of Hh and Wnt signaling pathways. | Kiselyov, AS., et al. 2007. Expert Opin Ther Targets. 11: 1087-101. PMID: 17665980
- Small-molecule modulators of the Sonic Hedgehog signaling pathway. | Stanton, BZ. and Peng, LF. 2010. Mol Biosyst. 6: 44-54. PMID: 20024066
- Drugging the cancer stem cell compartment: lessons learned from the hedgehog and Wnt signal transduction pathways. | Dodge, ME. and Lum, L. 2011. Annu Rev Pharmacol Toxicol. 51: 289-310. PMID: 20887197
- New hedgehog/GLI-signaling inhibitors from Adenium obesum. | Arai, MA., et al. 2011. Org Biomol Chem. 9: 1133-9. PMID: 21170436
- Physalin H from Solanum nigrum as an Hh signaling inhibitor blocks GLI1-DNA-complex formation. | Arai, MA., et al. 2014. Beilstein J Org Chem. 10: 134-40. PMID: 24454566
- Novel Small Molecule Inhibitors of Cancer Stem Cell Signaling Pathways. | Abetov, D., et al. 2015. Stem Cell Rev Rep. 11: 909-18. PMID: 26210995
- Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse model. | Lauressergues, E., et al. 2016. Pharmacol Res Perspect. 4: e00214. PMID: 27069629
- Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma. | Cucchi, D., et al. 2012. J Exp Pharmacol. 4: 173-85. PMID: 27186130
- Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells. | Qi, Y., et al. 2017. Nat Biotechnol. 35: 154-163. PMID: 28112759
- The Hedgehog pathway and its inhibitors: Emerging therapeutic approaches for basal cell carcinoma. | Jain, R., et al. 2022. Drug Discov Today. 27: 1176-1183. PMID: 34896624
- Topical Delivery of Hedgehog Inhibitors: Current Status and Perspectives. | Pedersen, KK., et al. 2022. Int J Mol Sci. 23: PMID: 36430669
Inhibitor of:
hedgehog, MACS1, patched, and Smo.Activator of:
hedgehog, and robo2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CUR 61414, 1 mg | sc-211143 | 1 mg | $380.00 |