Anti-CUG-BP1 Antibody (3B1) is a mouse monoclonal IgG1 κ CUG-BP1 antibody, cited in 71 publications, provided at 200 µg/ml
raised against full length CUG-BP1 fusion protein of human origin
Anti-CUG-BP1 Antibody (3B1) is recommended for detection of CUG-BP1 of mouse, rat and human origin by WB, IP, IF and IHC(P); also reactive with additional species, including and bovine and porcine
Anti-CUG-BP1 Antibody (3B1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of CUG-BP1 (3B1): sc-20003.
m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for CUG-BP1 Antibody (3B1) for WB and IHC(P) applications. This reagent is now offered in a bundle with CUG-BP1 Antibody (3B1) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Labware ships FedEx Ground free of charge to the contiguous US
CUG-BP1 Antibody (3B1) is a high quality monoclonal CUG-BP1 antibody (also designated CUG triplet repeat, RNA-binding protein 1 antibody, CUG-BP1 antibody, CUGBP antibody, 50 kDa nuclear polyadenylated RNA-binding protein antibody, NAB50 antibody, CUGBP, Elav-like family member 1 antibody, embryo deadenylation element binding protein antibody, EDEN-BP antibody, bruno-like 2 antibody, BRUNOL2 antibody, neuroblastoma apoptosis-related RNA-binding protein antibody, or NAPOR antibody) suitable for the detection of the CUG-BP1 protein of mouse, rat and human origin. CUG-BP1 Antibody (3B1) is available as both the non-conjugated anti-CUG-BP1 antibody form, as well as multiple conjugated forms of anti-CUG-BP1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Myotonic dystrophy (DM) is an autosomal dominant neuromuscular disease that is associated with a (CTG)n repeat expansion in the 3′-untranslated region of the myotonin protein kinase gene (DMPK). CUG-BP1 and CUG-BP2 are proteins that bind specifically to (CUG)8 oligonucleotides in vitro. While CUG-BP1 has the major binding activity in normal cells, nuclear CUG-BP2 binding activity increases in DM cells. Both CUG-BP1 and CUG-BP2 are isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. CUG-BP1, an RNA CUG triplet repeat binding protein, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the DMPK in DM is associated with alterations in binding activity of CUG-BP1 as well as alterations in the translation of the C/EBPb transcription factor. CUG-BP1 is an important regulator of initiation from different AUG codons of C/EBPb mRNA. In normal cells, CUG-BP1 up-regulates the p21 protein during differentiation by inducing the translation of p21 via binding to a GC-rich sequence located within the 5′ region of p21 mRNA. In DM cells, failure to accumulate CUG-BP1 leads to a reduction of p21 and alterations in other proteins responsible for cell cycle withdrawl.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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