Molecular structure of CUDA, CAS Number: 479413-68-8
CUDA (CAS 479413-68-8)
See product citations (2)
Alternate Names:
12- [[(cyclohexylamino)carbonyl]amino]- dodecanoic acid
Application:
CUDA is an sEH inhibitor and selective PPARα activator
CAS Number:
479413-68-8
Molecular Weight:
340.50
Molecular Formula:
C19H36N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CUDA is an inhibitor of sEH (soluble epoxide hydrolase, IC50 = 11.1 nM in mice). Studies have shown that 10 muM of CUDA can block the conversion of 14,15-EET to 14,15-DHET by 94% in COS-7 cells. CUDA selectively activates peroxisome proliferator-activated receptor α (PPARalpha) 8-fold at a concentration of 10 muM with no affect on PPARdelta or PPARgamma.
CUDA (CAS 479413-68-8) References
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- Enhancement of vitamin D metabolites in the eye following vitamin D3 supplementation and UV-B irradiation. | Lin, Y., et al. 2012. Curr Eye Res. 37: 871-8. PMID: 22632164
- Metabolite content profiling of bottlenose dolphin exhaled breath. | Aksenov, AA., et al. 2014. Anal Chem. 86: 10616-24. PMID: 25254551
- MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis. | Tsugawa, H., et al. 2015. Nat Methods. 12: 523-6. PMID: 25938372
- Enhanced non-invasive respiratory sampling from bottlenose dolphins for breath metabolomics measurements. | Zamuruyev, KO., et al. 2016. J Breath Res. 10: 046005. PMID: 27689905
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- Interferon γ treatment increases endocannabinoid and related N-acylethanolamine levels in T84 human colon carcinoma cells. | Alhouayek, M., et al. 2019. Br J Pharmacol. 176: 1470-1480. PMID: 29313885
- Comprehensive analysis of the mouse cytochrome P450 family responsible for omega-3 epoxidation of eicosapentaenoic acid. | Isobe, Y., et al. 2018. Sci Rep. 8: 7954. PMID: 29784972
- Rapid LC-MS/MS quantification of cancer related acetylated polyamines in human biofluids. | DeFelice, BC. and Fiehn, O. 2019. Talanta. 196: 415-419. PMID: 30683386
- Primed mesenchymal stem cells package exosomes with metabolites associated with immunomodulation. | Showalter, MR., et al. 2019. Biochem Biophys Res Commun. 512: 729-735. PMID: 30926165
- A Comprehensive Plasma Metabolomics Dataset for a Cohort of Mouse Knockouts within the International Mouse Phenotyping Consortium. | Barupal, DK., et al. 2019. Metabolites. 9: PMID: 31121816
- A Soluble Epoxide Hydrolase Inhibitor, 1-TrifluoromethoxyPhenyl-3-(1-Propionylpiperidin-4-yl) Urea, Ameliorates Experimental Autoimmune Encephalomyelitis. | Jonnalagadda, D., et al. 2021. Int J Mol Sci. 22: PMID: 33925035
- Metabolomics atlas of oral 13C-glucose tolerance test in mice. | Lopes, M., et al. 2021. Cell Rep. 37: 109833. PMID: 34644567
Inhibitor of:
sEH.Activator of:
PPAR alpha.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CUDA, 5 mg | sc-221443 | 5 mg | $57.00 | |||
CUDA, 10 mg | sc-221443A | 10 mg | $108.00 |