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CUDA is an inhibitor of soluble epoxide hydrolase (sEH, IC50 = 11.1 nM in mice). Studies have shown that 10 µM of CUDA can block the conversion of 14,15-EET to 14,15-DHET by 94% in COS-7 cells. CUDA selectively activates peroxisome proliferator-activated receptor α (PPARα) 8-fold at a concentration of 10 µM with no affect on PPARδ or PPARγ.
1. Morisseau, Christophe., et al., 2002. Structural refinement of inhibitors of urea-based soluble epoxide hydrolases. Biochemical pharmacology. 63(9): 1599-608. PMID: 12007563
2. Fleming, Ingrid., et al., 2004. Cytochrome P450 epoxygenases as EDHF synthase(s). Pharmacological research : the official journal of the Italian Pharmacological Society. 49(6): 525-33. PMID: 15026030
3. Fang, Xiang., et al., 2005. Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. The Journal of pharmacology and experimental therapeutics. 314(1): 260-70. PMID: 15798002
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