Cucurbitacin B (CAS 6199-67-3)
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Cucurbitacin B is a compound that has attracted significant interest in the field of plant biology and biochemistry due to its role as a natural product with strong biological activities. In research, Cucurbitacin B is primarily used to study its effects on cell signaling pathways and gene expression, particularly those involved in the regulation of cell division and growth. It is a tetracyclic triterpenoid that is found in various plant species, especially in the Cucurbitaceae family, which includes cucumbers and gourds. The compound′s distinctive structure allows for the exploration of its binding interactions with various proteins, providing insights into its mode of action at the molecular level. Additionally, Cucurbitacin B serves as a tool in agricultural research to understand plant defense mechanisms, as it can be a part of the plants′ response to herbivorous insects and other environmental stressors.
Cucurbitacin B (CAS 6199-67-3) References
- Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy. | Xiao, Y., et al. 2017. J Cell Biochem. 118: 3899-3910. PMID: 28390176
- Cucurbitacin B and cancer intervention: Chemistry, biology and mechanisms (Review). | Garg, S., et al. 2018. Int J Oncol. 52: 19-37. PMID: 29138804
- NLRP3 inflammasome inhibitor cucurbitacin B suppresses gout arthritis in mice. | Xue, Y., et al. 2021. J Mol Endocrinol. 67: 27-40. PMID: 34047713
- Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis. | Yuan, R., et al. 2021. Pharmacol Res. 170: 105748. PMID: 34217831
- Cucurbitacin B controls M2 macrophage polarization to suppresses metastasis via targeting JAK-2/STAT3 signalling pathway in colorectal cancer. | Zhang, H., et al. 2022. J Ethnopharmacol. 287: 114915. PMID: 34954267
- Cucurbitacin B regulates lung cancer cell proliferation and apoptosis via inhibiting the IL-6/STAT3 pathway through the lncRNA XIST/miR-let-7c axis. | Liu, JH., et al. 2022. Pharm Biol. 60: 154-162. PMID: 34967707
- Cucurbitacin B inhibits TGF-β1-induced epithelial-mesenchymal transition (EMT) in NSCLC through regulating ROS and PI3K/Akt/mTOR pathways. | Yuan, R., et al. 2022. Chin Med. 17: 24. PMID: 35183200
- Cucurbitacin B, Purified and Characterized From the Rhizome of Corallocarpus epigaeus Exhibits Anti-Melanoma Potential. | Aiswarya, SUD., et al. 2022. Front Oncol. 12: 903832. PMID: 35756619
- Cucurbitacin B Down-Regulates TNF Receptor 1 Expression and Inhibits the TNF-α-Dependent Nuclear Factor κB Signaling Pathway in Human Lung Adenocarcinoma A549 Cells. | Kusagawa, E., et al. 2022. Int J Mol Sci. 23: PMID: 35806134
- Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78-FOXM1-KIF20A pathway. | Wei, J., et al. 2022. Acta Pharm Sin B. 12: 3861-3876. PMID: 36213538
- Cucurbitacin-B Exerts Anticancer Effects through Instigation of Apoptosis and Cell Cycle Arrest within Human Prostate Cancer PC3 Cells via Downregulating JAK/STAT Signaling Cascade. | Alafnan, A., et al. 2022. Pharmaceuticals (Basel). 15: PMID: 36297341
- Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics. | Dai, S., et al. 2023. Pharmacol Res. 187: 106587. PMID: 36460279
- Cucurbitacin B-, E-, and I-Induced Browning of White Adipocytes Is Promoted by the Inhibition of Phospholipase D2. | Park, SY., et al. 2022. Int J Mol Sci. 23: PMID: 36499689
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cucurbitacin B, 5 mg | sc-483515 | 5 mg | $183.00 |