cubilin Antibody (A-4): sc-518089
- cubilin Antibody (A-4) is a mouse monoclonal IgM κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 51-73 near the N-terminus of cubilin of human origin
- recommended for detection of cubilin of human origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for cubilin Antibody (A-4) for WB applications. This reagent is now offered in a bundle with cubilin Antibody (A-4) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Cubilin Antibody (A-4) is a mouse monoclonal IgM antibody that detects cubilin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cubilin is an essential endocytic receptor that plays a critical role in the absorption of various ligands, including vitamin B12, apolipoprotein A1, and albumin, by facilitating their internalization in the intestine and kidney. Cubilin is characterized by a unique structure, which includes an amino terminal segment followed by eight epidermal growth factor (EGF)-like repeats and a series of 27 CUB domains, allowing cubilin to interact effectively with megalin, another receptor crucial for the uptake of cubilin-bound ligands. This interaction occurs specifically in the amino terminal region, where the EGF-like repeats and the first two CUB domains reside, highlighting the importance of cubilin′s structural integrity for function. Mutations in the cubilin gene can lead to megaloblastic anemia 1 (MGA1), a genetic disorder that results in the malabsorption of vitamin B12, underscoring cubilin′s vital role in nutrient uptake and overall health. Anti-cubilin antibody (A-4) is therefore a valuable tool for researchers studying the mechanisms of nutrient absorption and related disorders.
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cubilin Antibody (A-4) References:
- The tandem endocytic receptors megalin and cubilin are important proteins in renal pathology. | Verroust, PJ., et al. 2002. Kidney Int. 62: 745-56. PMID: 12164855
- Megalin and cubilin, role in proximal tubule function and during development. | Christensen, EI. and Verroust, PJ. 2002. Pediatr Nephrol. 17: 993-9. PMID: 12478347
- Cubilin is essential for albumin reabsorption in the renal proximal tubule. | Amsellem, S., et al. 2010. J Am Soc Nephrol. 21: 1859-67. PMID: 20798259
- Cubilin is expressed in rat and human glomerular podocytes. | Prabakaran, T., et al. 2012. Nephrol Dial Transplant. 27: 3156-9. PMID: 22337902
- Cubilin expression is monoallelic and epigenetically augmented via PPARs. | Aseem, O., et al. 2013. BMC Genomics. 14: 405. PMID: 23773363
- Tumoral cubilin is a predictive marker for treatment of renal cancer patients with sunitinib and sorafenib. | Niinivirta, M., et al. 2017. J Cancer Res Clin Oncol. 143: 961-970. PMID: 28260162
- Immunohistochemical localization of megalin and cubilin in the human inner ear. | Hosokawa, S., et al. 2018. Brain Res. 1701: 153-160. PMID: 30218661
- Cubilin-, megalin-, and Dab2-dependent transcription revealed by CRISPR/Cas9 knockout in kidney proximal tubule cells. | Long, KR., et al. 2022. Am J Physiol Renal Physiol. 322: F14-F26. PMID: 34747197
- Cubilin and amnionless protein are novel target antigens in anti-brush border antibody disease. | Morelle, J., et al. 2022. Kidney Int. 101: 1063-1068. PMID: 35276203
- Glycosylation of a key cubilin Asn residue results in reduced binding to albumin. | Yadav, SPS., et al. 2022. J Biol Chem. 298: 102371. PMID: 35970386
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cubilin Antibody (A-4) | sc-518089 | 200 µg/ml | $322.00 | |||
cubilin Antibody (A-4): m-IgGκ BP-HRP Bundle | sc-525359 | 200 µg Ab, 40 µg BP | $361.00 |