CTXL Antibody (ICO-44): sc-52391

CTXL Antibody (ICO-44) is a mouse monoclonal IgG1 antibody that detects the CTXL protein of human origin by western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). Anti-CTXL antibody (ICO-44) is available as the non-conjugated format. CTXL protein, also known as cortical thymocyte-like protein or VSIG2 (V-set and immunoglobulin domain-containing protein 2), plays a crucial role in immune regulation and cell signaling, particularly in T cell development and function. This 327 amino acid single-pass type-I membrane protein features one immunoglobulin-like C2-type domain and one immunoglobulin-like V-type domain, which are essential for protein interactions and mediating biological functions. CTXL shows predominant expression in tissues such as stomach, colon, prostate, trachea, and thyroid glands, while maintaining lower expression in bladder and lung. The gene encoding CTXL spans approximately 4,767 bases on human chromosome 11q24.2, a region associated with various genetic disorders, including Jervell and Lange-Nielsen syndrome and Jacobsen syndrome. Understanding CTXL function and expression patterns remains vital for elucidating roles in immune responses and potential implications in disease states, making CTXL (ICO-44) monoclonal antibody an invaluable research tool for studying these pathways.

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CTXL Antibody (ICO-44) References:

1. Hereditary angioedema. Long-term follow-up of 88 patients. Experience of the Argentine Allergy and Immunology Institute.  |  Fabiani, JE., et al. 2000. Allergol Immunopathol (Madr). 28: 267-71. PMID: 11270087
2. Smith-Lemli-Opitz syndrome and the DHCR7 gene.  |  Jira, PE., et al. 2003. Ann Hum Genet. 67: 269-80. PMID: 12914579
3. The pathogenesis and treatment of acid sphingomyelinase-deficient Niemann-Pick disease.  |  Schuchman, EH. 2007. J Inherit Metab Dis. 30: 654-63. PMID: 17632693
4. Jervell and Lange-Nielsen syndrome in Norwegian children: aspects around cochlear implantation, hearing, and balance.  |  Siem, G., et al. 2008. Ear Hear. 29: 261-9. PMID: 18595190
5. Chromosomal microarray mapping suggests a role for BSX and Neurogranin in neurocognitive and behavioral defects in the 11q terminal deletion disorder (Jacobsen syndrome).  |  Coldren, CD., et al. 2009. Neurogenetics. 10: 89-95. PMID: 18855024
6. An intronic mutation leading to incomplete skipping of exon-2 in KCNQ1 rescues hearing in Jervell and Lange-Nielsen syndrome.  |  Bhuiyan, ZA., et al. 2008. Prog Biophys Mol Biol. 98: 319-27. PMID: 19027783
7. CTX, a Xenopus thymocyte receptor, defines a molecular family conserved throughout vertebrates.  |  Chrétien, I., et al. 1998. Eur J Immunol. 28: 4094-104. PMID: 9862345

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CTXL Antibody (ICO-44) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-CTXL Antibody (ICO-44) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CTXL Antibody (ICO-44) Specifications

Alternate Product Name: CTXL

Product Clone Name: ICO-44

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: CTXL

Epitope Species: human

Product Reactivity/Detection: CTXL

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, FCM

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for CTXL Antibody (ICO-44): N/A