Molecular structure of CTPB, CAS Number: 586976-24-1
CTPB (CAS 586976-24-1)
See product citations (4)
Alternate Names:
CTPB is known as a p300 HAT activator.
Application:
CTPB is a potent and selective histone acetyltransferase (HAT) p300 activator, able to directly bind p300.
CAS Number:
586976-24-1
Purity:
≥97%
Molecular Weight:
554.13
Molecular Formula:
C31H43ClF3NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CTPB is an amide derivative also known as N-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxy-6-pentadecyl-benzamide. CTPB is an activator of p300 histone acetyltransferase (HAT) activity. HATs are groups of enzymes that play a important role in regulation of gene expression. CTPB may act to enhance p300 HAT-dependent transcriptional activation from in vitro assembled chromatin template. CTPB has also been noted to be a membrane-impermeable molecule that requires a carrier to move across the membrane barrier of cells.
CTPB (CAS 586976-24-1) References
- Small molecule modulators of histone acetyltransferase p300. | Balasubramanyam, K., et al. 2003. J Biol Chem. 278: 19134-40. PMID: 12624111
- Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. | Balasubramanyam, K., et al. 2004. J Biol Chem. 279: 51163-71. PMID: 15383533
- SpoIVB and CtpB are both forespore signals in the activation of the sporulation transcription factor sigmaK in Bacillus subtilis. | Campo, N. and Rudner, DZ. 2007. J Bacteriol. 189: 6021-7. PMID: 17557826
- Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases. | Sbardella, G., et al. 2008. Bioorg Med Chem Lett. 18: 2788-92. PMID: 18434144
- Intrinsically fluorescent carbon nanospheres as a nuclear targeting vector: delivery of membrane-impermeable molecule to modulate gene expression in vivo. | Selvi, BR., et al. 2008. Nano Lett. 8: 3182-8. PMID: 18800851
- New anacardic acid-inspired benzamides: histone lysine acetyltransferase activators. | Souto, JA., et al. 2010. ChemMedChem. 5: 1530-40. PMID: 20683922
- Exploring the binding affinities of p300 enzyme activators CTPB and CTB using docking method. | Devipriya, B., et al. 2010. Indian J Biochem Biophys. 47: 364-9. PMID: 21355420
- Emerging roles of anacardic acid and its derivatives: a pharmacological overview. | Hemshekhar, M., et al. 2012. Basic Clin Pharmacol Toxicol. 110: 122-32. PMID: 22103711
- Charge density distribution and the electrostatic moments of CTPB in the active site of p300 enzyme: a DFT and charge density study. | Devipriya, B. and Kumaradhas, P. 2013. J Theor Biol. 335: 119-29. PMID: 23770402
- A Small Molecule Activator of p300/CBP Histone Acetyltransferase Promotes Survival and Neurite Growth in a Cellular Model of Parkinson's Disease. | Hegarty, SV., et al. 2016. Neurotox Res. 30: 510-20. PMID: 27256286
- Mono-ADP-ribosylation of histone 3 at arginine-117 promotes proliferation through its interaction with P300. | Ling, F., et al. 2017. Oncotarget. 8: 72773-72787. PMID: 29069825
- p300 suppresses leukemia development in NUP98-HOXD13 driven myelodysplastic syndrome. | Man, N. and Nimer, SD. 2018. Oncotarget. 9: 26603-26604. PMID: 29928471
- The Involvement of Histone H3 Acetylation in Bovine Herpesvirus 1 Replication in MDBK Cells. | Zhu, L., et al. 2018. Viruses. 10: PMID: 30261679
- Investigation of activation mechanism and conformational stability of N-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxybenzamide and N-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxy-6-pentadecyl-benzamide in the: active site of p300 histone acetyl transferase enzyme by molecular dynamics and binding free energy studies. | Sivanandam, M., et al. 2019. J Biomol Struct Dyn. 37: 4006-4018. PMID: 30301423
Activator of:
p300.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CTPB, 1 mg | sc-202558 | 1 mg | $58.00 | |||
CTPB, 5 mg | sc-202558A | 5 mg | $162.00 |