CT-R Antibody (2F7): sc-293299

CT-R Antibody (2F7) is a mouse monoclonal IgG2a kappa light chain antibody that detects CT-R protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-CT-R antibody (2F7) is available as the non-conjugated form. CT-R protein, also known as calcitonin receptor, plays a crucial role in calcium homeostasis by mediating the effects of the peptide hormone calcitonin, which is secreted by the thyroid gland. CT-R (2F7) antibody recognizes a distinct family of seven transmembrane proteins that includes receptors for parathyroid hormone, secretin, and glucagon. CT-R protein is primarily located on the surface of osteoclasts and renal cells, where CT-R (2F7) monoclonal antibody initiates intracellular signaling cascades by coupling with various heterotrimeric G-proteins. This interaction activates multiple signaling pathways, including those involving adenylyl cyclase and phospholipase C, which are essential for regulating bone resorption and calcium levels in the bloodstream. The gene encoding CT-R is characterized by numerous exons and larger introns, allowing for the production of multiple splice variants that exhibit unique functional properties and tissue distributions. These isoforms preferentially associate with specific G-proteins, leading to the recruitment of distinct signaling intermediates, which is vital for the precise regulation of calcium homeostasis and overall metabolic balance. In osteoclasts and embryonic kidney cells, calcitonin binding to CT-R activates the mitogen-activated protein kinases Erk1/2 and protein kinase C through the phosphorylation of adaptor proteins such as Shc and HEF1, demonstrating CT-R′s ability to mediate complex signaling independently of traditional pathways like protein kinase A and adenylyl cyclase.

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CT-R Antibody (2F7) References:

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