Date published: 2026-4-25

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Crosstide (CAS 171783-05-4)

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CAS Number:
171783-05-4
Purity:
≥97%
Molecular Weight:
1165.2
Molecular Formula:
C48H77N17O17
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Crosstide is an innovative tool based on peptides, specifically designed to aid researchers in unraveling the intricacies of protein-protein interactions. This versatile technology has proven invaluable in investigating a broad spectrum of biological processes, encompassing signal transduction, enzyme kinetics, and protein folding. Crosstide has found extensive application across scientific research endeavors, serving as a powerful tool in the examination of protein-protein interactions, enzyme kinetics, and protein folding. The mechanism behind Crosstide′s effectiveness lies in its ability to mimic the binding site of a specific protein. By binding to the target protein and interfering with its function, Crosstide enables researchers to observe the resulting effects of this disruption.


Crosstide (CAS 171783-05-4) References

  1. Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction.  |  Dai, F., et al. 2002. Biochem Biophys Res Commun. 293: 1191-6. PMID: 12054501
  2. Activation of a GST-tagged AKT2/PKBbeta.  |  Baer, K., et al. 2005. Biochim Biophys Acta. 1725: 340-7. PMID: 15890450
  3. Improved yields for baculovirus-mediated expression of human His(6)-PDK1 and His(6)-PKBbeta/Akt2 and characterization of phospho-specific isoforms for design of inhibitors that stabilize inactive conformations.  |  Gao, X., et al. 2005. Protein Expr Purif. 43: 44-56. PMID: 16084396
  4. Rhinovirus activates interleukin-8 expression via a Src/p110beta phosphatidylinositol 3-kinase/Akt pathway in human airway epithelial cells.  |  Bentley, JK., et al. 2007. J Virol. 81: 1186-94. PMID: 17121804
  5. Peripheral muscle strength is associated with lung function and functional capacity in patients with cystic fibrosis.  |  Rovedder, PME., et al. 2019. Physiother Res Int. 24: e1771. PMID: 30776177
  6. Assessment of impact of a skin cancer education session on cosmetology students' knowledge and preparedness to assess future clients for skin lesions.  |  Radisic, A., et al. 2020. J Cosmet Dermatol. 19: 205-210. PMID: 31081582
  7. Determination of leucocyte extracellular traps (ETs) in seminal fluid (ex vivo) in infertile patients-A pilot study.  |  Schulz, M., et al. 2019. Andrologia. 51: e13356. PMID: 31287181
  8. Indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase expression in HPV infection, SILs, and cervical cancer.  |  Venancio, PA., et al. 2019. Cancer Cytopathol. 127: 586-597. PMID: 31412167
  9. Alternative AKT2 splicing produces protein lacking the hydrophobic motif regulatory region.  |  Plotz, G., et al. 2020. PLoS One. 15: e0242819. PMID: 33253205
  10. In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate.  |  Pokorny, D., et al. 2021. J Biol Chem. 297: 100919. PMID: 34181950
  11. A PDK-1 allosteric agonist neutralizes insulin signaling derangements and beta-amyloid toxicity in neuronal cells and in vitro.  |  Querfurth, H., et al. 2022. PLoS One. 17: e0261696. PMID: 35061720
  12. Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation.  |  Levina, A., et al. 2022. Nat Commun. 13: 1874. PMID: 35387990
  13. Identification of a new structural family of SGK1 inhibitors as potential neuroprotective agents.  |  Maestro, I., et al. 2023. J Enzyme Inhib Med Chem. 38: 2153841. PMID: 36637025
  14. Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta.  |  Meier, R., et al. 1997. J Biol Chem. 272: 30491-7. PMID: 9374542

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Crosstide, 1 mg

sc-471145
1 mg
$208.00