Crocin (CAS 42553-65-1)
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Crocin is the coloring principle of saffron which comes from the styles of Crocus sativus, Iridaceae. Crocin as well as its aglucone derivative, crocetin dimethyl ester, play a role in the sex process of algae of the Chlamydomonas group. Crocin is also a potent antioxidant. It has been found to have an inhibitory effect on the activity of enzymes involved in lipid metabolism, such as lipoxygenase and cyclooxygenase. It also has anti-cancer activity, which is due to its ability to induce apoptosis and inhibit cell proliferation. Additionally, it has an inhibitory effect on the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha and interleukin-6. Moreover, it hinders the growth of several bacteria, including Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
Crocin (CAS 42553-65-1) References
- Pharmacokinetic Properties of Saffron and its Active Components. | Hosseini, A., et al. 2018. Eur J Drug Metab Pharmacokinet. 43: 383-390. PMID: 29134501
- The protective effects of crocin in the management of neurodegenerative diseases: a review. | Farkhondeh, T., et al. 2018. Am J Neurodegener Dis. 7: 1-10. PMID: 29531865
- Investigation of the neuroprotective effects of crocin via antioxidant activities in HT22 cells and in mice with Alzheimer's disease. | Wang, C., et al. 2019. Int J Mol Med. 43: 956-966. PMID: 30569175
- Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention. | Colapietro, A., et al. 2019. Anticancer Agents Med Chem. 19: 38-47. PMID: 30599111
- Therapeutic potentials of crocin in medication of neurological disorders. | Ahmed, S., et al. 2020. Food Chem Toxicol. 145: 111739. PMID: 32916219
- Novel Neuroprotective Potential of Crocin in Neurodegenerative Disorders: An Illustrated Mechanistic Review. | Kermanshahi, S., et al. 2020. Neurochem Res. 45: 2573-2585. PMID: 32940861
- Prospects and progress on crocin biosynthetic pathway and metabolic engineering. | Liu, T., et al. 2020. Comput Struct Biotechnol J. 18: 3278-3286. PMID: 33209212
- Protective role of crocin against sepsis-induced injury in the liver, kidney and lungs via inhibition of p38 MAPK/NF-κB and Bax/Bcl-2 signalling pathways. | Gao, J., et al. 2022. Pharm Biol. 60: 543-552. PMID: 35225146
- Crocin as a vision supplement. | Heydari, M., et al. 2023. Clin Exp Optom. 106: 249-256. PMID: 35231199
- Anti-Depressant Properties of Crocin Molecules in Saffron. | Siddiqui, SA., et al. 2022. Molecules. 27: PMID: 35408474
- Crocin Inhibits Angiogenesis and Metastasis in Colon Cancer via TNF-α/NF-kB/VEGF Pathways. | Bakshi, HA., et al. 2022. Cells. 11: PMID: 35563808
- An evaluation on potential anti-oxidant and anti-inflammatory effects of Crocin. | Bastani, S., et al. 2022. Biomed Pharmacother. 153: 113297. PMID: 35738178
- Crocin molecular signaling pathways at a glance: A comprehensive review. | Boozari, M. and Hosseinzadeh, H. 2022. Phytother Res. 36: 3859-3884. PMID: 35989419
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Crocin, 1 g | sc-217957 | 1 g | $56.00 | |||
Crocin, 5 g | sc-217957A | 5 g | $251.00 |