CRISP-8 Antibody (I-7): sc-130452

CRISP-8 Antibody (I-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects CRISP-8 protein of human origin by immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-CRISP-8 antibody (I-7) is available as the non-conjugated form. Cysteine-rich secretory proteins (CRISPs) are a family of evolutionarily conserved proteins that play a significant role in the innate immune system and are transcriptionally regulated by androgens in various tissues. CRISP-8, also known as PI15 (Peptidase inhibitor 15), P25TI, or SugarCrisp, is a 258 amino acid secreted protein that belongs to the CRISP family. CRISP-8 is expressed at low levels in thyroid, prostate, salivary, and mammary tissues, functioning primarily as a serine protease inhibitor with weak inhibitory action against Trypsin, a serine protease involved in digestion. Notably, CRISP-8 is secreted in neuroblastoma and glioblastoma cell lines, indicating potential involvement in tumor formation and metastasis within the central nervous system. CRISP-8′s ability to interact with specific serine proteases highlights its importance in regulating proteolytic activity, which can influence various physiological and pathological processes, including inflammation and cancer progression.

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CRISP-8 Antibody (I-7) References:

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