CRF Antibody (2B11): sc-293187

CRF Antibody (2B11) is a mouse monoclonal IgG2a kappa light chain antibody that detects corticotropin-releasing factor (CRF) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-CRF antibody (2B11) is available as a non-conjugated format, which is crucial for studying CRF′s role in various physiological and pathological processes. CRF is primarily located in the hypothalamus, where CRF plays a vital role in stress response by regulating the hypothalamic-pituitary-adrenal (HPA) axis. This regulation is essential for maintaining homeostasis during stress, as CRF stimulates the release of adrenocorticotropic hormone (ACTH) from the pituitary gland, which in turn promotes cortisol release from the adrenal glands. Dysregulation of CRF signaling has been implicated in several neuropsychiatric disorders, including anxiety and depression, highlighting the importance of understanding CRF′s cellular localization and function. Furthermore, alterations in CRF levels have been observed in conditions such as Alzheimer′s disease, where reduced CRF content correlates with cognitive impairment, making CRF monoclonal antibody (2B11) a valuable tool for investigating the molecular mechanisms underlying these diseases.

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CRF Antibody (2B11) References:

1. Understanding Corticotropin Releasing Factor Receptor (CRFR) Activation Using Structural Models.  |  Cordomi, A., et al. 2017. Curr Mol Pharmacol. 10: 325-333. PMID: 28103783
2. Corticotropin-Releasing Factor (CRF) and Addictive Behaviors.  |  Roberto, M., et al. 2017. Int Rev Neurobiol. 136: 5-51. PMID: 29056155
3. Corticotropin-Releasing Factor (CRF) circuit modulation of cognition and motivation.  |  Hupalo, S., et al. 2019. Neurosci Biobehav Rev. 103: 50-59. PMID: 31212019
4. Role of corticotropin-releasing factor in alcohol and nicotine addiction.  |  Simpson, S., et al. 2020. Brain Res. 1740: 146850. PMID: 32330519
5. Corticotropin releasing factor modulates excitatory synaptic transmission.  |  Joshi, N., et al. 2020. Vitam Horm. 114: 53-69. PMID: 32723550
6. Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression.  |  Chalmers, DT., et al. 1995. J Neurosci. 15: 6340-50. PMID: 7472399
7. Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease.  |  Behan, DP., et al. 1995. Nature. 378: 284-7. PMID: 7477348
8. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor.  |  Vaughan, J., et al. 1995. Nature. 378: 287-92. PMID: 7477349
9. CRF2 alpha and CRF2 beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues.  |  Lovenberg, TW., et al. 1995. Endocrinology. 136: 4139-42. PMID: 7544278
10. Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid.  |  Liaw, CW., et al. 1996. Endocrinology. 137: 72-7. PMID: 8536644
11. Corticotropin releasing factor (CRF) binding protein: a novel regulator of CRF and related peptides.  |  Behan, DP., et al. 1995. Front Neuroendocrinol. 16: 362-82. PMID: 8557170
12. Corticotropin releasing factor binding protein (CRF-BP) is expressed in neuronal and astrocytic cells.  |  Behan, DP., et al. 1995. Brain Res. 698: 259-64. PMID: 8581494

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CRF Antibody (2B11) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-CRF Antibody (2B11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CRF Antibody (2B11) Specifications

Alternate Product Name: Corticotropin releasing hormone

Product Clone Name: 2B11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 154-196

Epitope Target: CRF

Epitope Species: human

Product Reactivity/Detection: CRF

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for CRF Antibody (2B11): N/A