CRE-BPa Antibody (G420): sc-130435

CRE-BPa Antibody (G420) is a mouse monoclonal IgG2a kappa light chain antibody that detects CRE-BPa protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CRE-BPa antibody (G420) is available as the non-conjugated format. CRE-BPa protein plays a crucial role in regulating gene expression as a transcription factor, specifically by binding to the cAMP responsive element (CRE) within promoter regions of target genes. CRE-BPa binding is essential for mediating cellular responses to various signals, including hormones and growth factors, which influence processes such as cell proliferation, differentiation, and survival. CRE-BPa forms homodimers and heterodimers with other transcription factors, such as ATF-2 and Jun, enhancing regulatory capacity and allowing for complex interplay of signaling pathways that dictate cellular outcomes. CRE-BPa′s interaction with coactivators like CREB-binding protein (CBP) upon phosphorylation by protein kinase A further underscores importance in transcriptional regulation. This multifaceted role in gene expression highlights significance in various physiological and pathological processes, making CRE-BPa a valuable target for research in cellular signaling and transcriptional control.

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CRE-BPa Antibody (G420) References:

1. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.  |  Iourgenko, V., et al. 2003. Proc Natl Acad Sci U S A. 100: 12147-52. PMID: 14506290
2. Role of basic region leucine zipper transcription factors cyclic AMP response element binding protein (CREB), CREB2, activating transcription factor 2 and CAAT/enhancer binding protein alpha in cyclic AMP response element-mediated transcription.  |  Thiel, G., et al. 2005. J Neurochem. 92: 321-36. PMID: 15663480
3. Regulation of GTP cyclohydrolase I gene transcription by basic region leucine zipper transcription factors.  |  Al Sarraj, J., et al. 2005. J Cell Biochem. 96: 1003-20. PMID: 16149046
4. Nonclassical progesterone signalling molecules in the nervous system.  |  Petersen, SL., et al. 2013. J Neuroendocrinol. 25: 991-1001. PMID: 23763432
5. Novel progesterone receptors: neural localization and possible functions.  |  Petersen, SL., et al. 2013. Front Neurosci. 7: 164. PMID: 24065878
6. PAQR6 Expression Enhancement Suggests a Worse Prognosis in Prostate Cancer Patients.  |  Li, B., et al. 2018. Open Life Sci. 13: 511-517. PMID: 33817121
7. Copy Number Variations of CEP63, FOSL2 and PAQR6 Serve as Novel Signatures for the Prognosis of Bladder Cancer.  |  Cai, Z., et al. 2021. Front Oncol. 11: 674933. PMID: 34041036
8. Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease.  |  Chen, S., et al. 2022. Acta Neuropathol Commun. 10: 188. PMID: 36544231
9. PAQR6 as a prognostic biomarker and potential therapeutic target in kidney renal clear cell carcinoma.  |  Zou, T., et al. 2024. Front Immunol. 15: 1521629. PMID: 39742277
10. Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter TPA.  |  Zu, YL., et al. 1993. Oncogene. 8: 2749-58. PMID: 8378084
11. Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1.  |  Nomura, N., et al. 1993. J Biol Chem. 268: 4259-66. PMID: 8440710
12. delta opioid receptors stimulate Akt-dependent phosphorylation of c-jun in T cells.  |  Shahabi, NA., et al. 2006. J Pharmacol Exp Ther. 316: 933-9. PMID: 16249373

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CRE-BPa Antibody (G420) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-CRE-BPa Antibody (G420) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CRE-BPa Antibody (G420) Specifications

Alternate Product Name: CRE-BPa

Product Clone Name: G420

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-100

Epitope Target: CRE-BPa

Epitope Species: human

Product Reactivity/Detection: CRE-BPa

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for CRE-BPa Antibody (G420): N/A