CRBP II Antibody (8-1#): sc-517437
- CRBP II Antibody (8-1#) is a mouse monoclonal IgG2b κ CRBP II antibody provided at 100 µg/ml
- raised against a recombinant protein corresponding to amino acids 1-134 of CRBP II of human origin
- recommended for detection of CRBP II of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CRBP II Antibody (8-1#). This work is in progress.
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CRBP II Antibody (8-1#) is a mouse monoclonal IgG2b kappa light chain antibody that detects CRBP II protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-CRBP II antibody (8-1#) is available as the non-conjugated form. The cellular retinol-binding proteins, including CRBP I, II, III, and IV, are crucial for the transport and metabolism of vitamin A, a vital nutrient for numerous biological processes such as cell growth, differentiation, and vision. CRBP II, also known as retinol-binding protein 2, is specifically expressed in the small intestine, where CRBP II plays a pivotal role in the absorption of retinoids and carotenoids, facilitating the biosynthesis of retinyl esters. Structurally, CRBP II consists of 134 amino acids and features a unique arrangement of ten antiparallel β-strands that form a β-barrel, encapsulating the retinol molecule, along with two α-helices that cover the open ends of the barrel. This structural configuration enables effective binding and transport of retinol, ensuring vitamin A availability for critical physiological processes. CRBP II′s ability to interact with retinol and other hydrophobic ligands underscores CRBP II′s importance in maintaining vitamin A homeostasis and supporting overall health.
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CRBP II Antibody (8-1#) References:
- Regulation of vitamin A metabolism-related gene expression. | Takase, S., et al. 2000. Br J Nutr. 84 Suppl 2: S217-21. PMID: 11242473
- Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein. | Folli, C., et al. 2001. Proc Natl Acad Sci U S A. 98: 3710-5. PMID: 11274389
- Regulation of alpha-smooth muscle actin and CRBP-1 expression by retinoic acid and TGF-beta in cultured fibroblasts. | Xu, G., et al. 2001. J Cell Physiol. 187: 315-25. PMID: 11319755
- Quantitation of cellular retinol-binding protein in human organs. | Ong, DE. and Page, DL. 1986. Am J Clin Nutr. 44: 425-30. PMID: 3751963
- Crystallographic studies on a family of cellular lipophilic transport proteins. Refinement of P2 myelin protein and the structure determination and refinement of cellular retinol-binding protein in complex with all-trans-retinol. | Cowan, SW., et al. 1993. J Mol Biol. 230: 1225-46. PMID: 7683727
- [Cellular retinoid-binding proteins]. | Okuno, M., et al. 1993. Nihon Rinsho. 51: 879-85. PMID: 8387121
- Crystal structures of holo and apo-cellular retinol-binding protein II. | Winter, NS., et al. 1993. J Mol Biol. 230: 1247-59. PMID: 8487303
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CRBP II Antibody (8-1#) | sc-517437 | 100 µg/ml | $316.00 |