cPLA2 Antibody (E-1): sc-376618
- cPLA2 Antibody (E-1) is a mouse monoclonal IgG1 κ cPLA2 antibody, cited in 7 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 721-752 at the C-terminus of cPLA2 of human origin
- recommended for detection of cytosolic PLA2 of mouse, rat and human origin by WB, IP, IF and ELISA
- See cPLA2 (4-4B-3C): sc-454 for cPLA2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for cPLA2 Antibody (E-1) for WB applications. These reagents are now offered in bundles with cPLA2 Antibody (E-1) (see ordering information below).
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cPLA2 Antibody (E-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects cPLA2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-cPLA2 antibody (E-1) is available as the non-conjugated form. cPLA2 protein, also known as cytosolic phospholipase A2, plays a crucial role in the hydrolysis of membrane phospholipids, specifically targeting the sn-2-acyl ester bond. This enzymatic activity is vital for the release of arachidonic acid, a key precursor in the biosynthesis of eicosanoids, which include potent inflammatory mediators such as prostaglandins and leukotrienes. cPLA2 protein generates these bioactive lipids essential for various physiological processes, including inflammation, pain response, and immune regulation. cPLA2 protein is predominantly located in the cytosol of various cell types, including platelets, macrophages, and monoblasts, where activation occurs in response to increases in intracellular calcium levels. This localization allows for rapid mobilization of arachidonic acid in response to cellular signals, thereby influencing inflammatory responses and other critical cellular functions.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cPLA2 Antibody (E-1) | sc-376618 | 200 µg/ml | $316.00 | |||
cPLA2 Antibody (E-1): m-IgG Fc BP-HRP Bundle | sc-540613 | 200 µg Ab; 10 µg BP | $354.00 | |||
cPLA2 Antibody (E-1): m-IgG1 BP-HRP Bundle | sc-542245 | 200 µg Ab; 20 µg BP | $354.00 | |||
cPLA2 (E-1) Neutralizing Peptide | sc-376618 P | 100 µg/0.5 ml | $68.00 |