CPH hydrochloride CAS: 92416-28-9
MF: C9H17NO3•HCl
MW: 223.7
A spin trap for the detection of superoxide radicals and peroxynitrite.

CPH hydrochloride (CAS 92416-28-9)

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Alternate Names: 1-Hydroxy-3-carboxy-2,2,5,5-tetramethylpyrrolidine . HCl
Application: CPH hydrochloride is a spin trap for the detection of superoxide radicals and peroxynitrite
CAS Number: 92416-28-9
Molecular Weight: 223.7
Molecular Formula: C9H17NO3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

CPH hydrochloride is an effective, cell permeable and non-toxic spin trap for the detection of superoxide radical and peroxynitrite, in vitro . Resistant to reduction by vitamin C and thiols.


References

Spin trapping of superoxide radicals and peroxynitrite by 1-hydroxy-3- carboxy-pyrrolidine and 1-hydroxy-2,2,6, 6-tetramethyl-4-oxo-piperidine and the stability of corresponding nitroxyl radicals towards biological reductants: S. Dikalov, et al.; BBRC 231, 701 (1997) Quantification of superoxide radicals and peroxynitrite in vascular cells using oxidation of sterically hindered hydroxylamines and electron spin resonance: S. Dikalov, et al.; Nitric Oxide 1, 423 (1997) Comparison of glyceryl trinitrate-induced with pentaerythrityl tetranitrate-induced in vivo formation of superoxide radicals: effect of vitamin C: S. Dikalov, et al.; Free Radic. Biol. Med. 27, 170 (1999) A new approach for extracellular spin trapping of nitroglycerin-induced superoxide radicals both in vitro and in vivo: B. Fink, et al.; Free Radic. Biol. Med. 28, 121 (2000) Noninvasive diagnostic tool for inflammation-induced oxidative stress using electron spin resonance spectroscopy and an extracellular cyclic hydroxylamine: S.I. Dikalov, et al.; Arch. Biochem. Biophys. 402, 218 (2002) Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase: N. Kuzkaya, et al.; J. Biol. Chem. 278, 22546 (2003) Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase: N. Kuzkaya, et al.; Biochem. Pharmacol. 70, 343 (2005) Indoxyl sulfate induces complex redox alterations in mesangial cells: A.K. Gelasco & J.R. Raymond; Am. J. Physiol. Renal Physiol. 290, F1551 (2006)

Physical State :
Solid
Solubility :
Soluble in DMSO, ethanol (100%), methanol, water (10 mg/ml) at 25° C, PBS pH 7.2, and DMF.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
57347465
SMILES :
CC1(CC(C(N1O)(C)C)C(=O)O)C.Cl

Download SDS (MSDS)

Certificate of Analysis

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