Molecular structure of CP 96345, CAS Number: 132746-60-2
CP 96345 (CAS 132746-60-2)
See product citations (1)
Alternate Names:
(2S,3S)-cis-2-(Diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine
Application:
CP 96345 is a selective and potent non-peptide NK1receptor antagonist
CAS Number:
132746-60-2
Purity:
≥98%
Molecular Weight:
412.57
Molecular Formula:
C28H32N2O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CP 96345 is a compound that has been the focus of research in the field of biochemistry, particularly in the study of receptor-ligand interactions. It serves as useful in the investigation of the function of certain receptors, where it may act as an antagonist. Research involving CP 96345 often aims to elucidate the signaling pathways and cellular responses mediated by these receptors. Furthermore, it is used in the study of its binding affinity and selectivity, which is critical for understanding the molecular basis of receptor activation and inhibition. In addition, CP 96345 is employed in various assays to examine the physiological responses in cells or tissues upon receptor interaction, providing insights into the complex mechanisms of intracellular signaling.
CP 96345 (CAS 132746-60-2) References
- Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury. | Bang, R., et al. 2003. J Pharmacol Exp Ther. 305: 31-9. PMID: 12649350
- CP-96,345 antagonism of NK1 receptors and smoke-induced protein extravasation in relation to its cardiovascular effects. | Delay-Goyet, P., et al. 1992. Eur J Pharmacol. 222: 213-8. PMID: 1280591
- The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation. | Lembeck, F., et al. 1992. Br J Pharmacol. 105: 527-30. PMID: 1378337
- Intrathecal CP-96,345 blocks reflex facilitation induced in rats by substance P and C-fiber-conditioning stimulation. | Xu, XJ., et al. 1992. Eur J Pharmacol. 216: 337-44. PMID: 1385160
- A potent nonpeptide antagonist of the substance P (NK1) receptor. | Snider, RM., et al. 1991. Science. 251: 435-7. PMID: 1703323
- Substance P antagonist CP-96345 blocks lung vascular leakage and inflammation more effectively than its stereoisomer CP-96344 in a mouse model of smoke inhalation and burn injury. | Jacob, S., et al. 2010. Toxicol Mech Methods. 20: 197-203. PMID: 20201741
- Blockade of tachykinin NK1 receptors by CP-96345 enhances dopamine release and the striatal dopamine effects of methamphetamine in rats. | Gygi, SP., et al. 1993. Eur J Pharmacol. 250: 177-80. PMID: 7509751
- Antagonism of nociceptive responses of cat spinal dorsal horn neurons in vivo by the NK-1 receptor antagonists CP-96,345 and CP-99,994, but not by CP-96,344. | Radhakrishnan, V. and Henry, JL. 1995. Neuroscience. 64: 943-58. PMID: 7538641
- CP-96,345, but not its stereoisomer, CP-96,344, blocks the nociceptive responses to intrathecally administered substance P and to noxious thermal and chemical stimuli in the rat. | Yashpal, K., et al. 1993. Neuroscience. 52: 1039-47. PMID: 7680799
- Different binding epitopes on the NK1 receptor for substance P and non-peptide antagonist. | Gether, U., et al. 1993. Nature. 362: 345-8. PMID: 7681152
- Discovery of CP-96,345 and its characterization in disease models involving substance P. | Lowe, JA., et al. 1993. Regul Pept. 46: 20-3. PMID: 7692490
- Differences in the potency of CP-96345 and RP-67580, two new non-peptide antagonists selective for NK1 receptors, in inhibiting responses evoked by stimulation of sensory nerves. | Delay-Goyet, P., et al. 1993. Regul Pept. 46: 304-6. PMID: 7692522
- The interaction of the NK1 receptor antagonist CP-96,345 with L-type calcium channels and its functional consequences. | Guard, S., et al. 1993. Br J Pharmacol. 110: 385-91. PMID: 7693284
- Cardiovascular effects of CP-96,345, a non-peptide blocker of tachykinin NK1 receptors. | Constantine, JW., et al. 1994. Eur J Pharmacol. 252: 275-82. PMID: 8162950
- Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345. | Fong, TM., et al. 1993. Nature. 362: 350-3. PMID: 8384323
Inhibitor of:
ACCβ, NK-1R, and Preprotachykinin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CP 96345, 5 mg | sc-361160 | 5 mg | $340.00 | |||
CP 96345, 25 mg | sc-361160A | 25 mg | $849.00 |