Molecular structure of CP 94253 hydrochloride, CAS Number: 131084-35-0
CP 94253 hydrochloride (CAS 131084-35-0)
Alternate Names:
5-Propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridin hydrochloride
Application:
CP 94253 hydrochloride is a potent and selective SR-1B agonist
CAS Number:
131084-35-0
Purity:
≥98%
Molecular Weight:
293.79
Molecular Formula:
C15H19N3O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CP 94253 hydrochloride is a chemical compound often used in research applications to investigate neurological mechanisms, particularly those related to the serotonin (5-HT) system. This compound acts as a selective agonist for the 5-HT1B receptor subtype, which allows researchers to study the effects of this receptor′s activation on neurotransmitter release. Studies involving CP 94253 hydrochloride contribute to a more comprehensive understanding of how serotonergic signaling influences various processes. Additionally, the application of this compound in experimental models enables the exploration of the role of 5-HT1B receptors in the modulation of circadian rhythms and neurovascular function.
CP 94253 hydrochloride (CAS 131084-35-0) References
- Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT(1B) receptor agonist CP-94,253. | Fish, EW., et al. 1999. Psychopharmacology (Berl). 146: 391-9. PMID: 10550489
- Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat. | Schreiber, R. and De Vry, J. 2002. Prog Neuropsychopharmacol Biol Psychiatry. 26: 441-9. PMID: 11999893
- 5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253. | Lee, MD., et al. 2002. Psychopharmacology (Berl). 164: 49-60. PMID: 12373419
- Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: a possible mechanism of action. | Tatarczyńska, E., et al. 2005. Eur J Pharmacol. 516: 46-50. PMID: 15913599
- Anticonvulsant effect of the selective 5-HT1B receptor agonist CP 94253 in mice. | Wesołowska, A., et al. 2006. Eur J Pharmacol. 541: 57-63. PMID: 16765343
- Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors. | Nonogaki, K., et al. 2007. Int J Neuropsychopharmacol. 10: 675-81. PMID: 16959056
- 5-HT 1B receptor-mediated serotoninergic modulation of methylphenidate-induced locomotor activation in rats. | Borycz, J., et al. 2008. Neuropsychopharmacology. 33: 619-26. PMID: 17487226
- Activation of serotonin 5-HT(1B) receptor in the dorsal raphe nucleus affects REM sleep in the rat. | Monti, JM., et al. 2010. Behav Brain Res. 206: 8-16. PMID: 19737581
- Subtype-specific changes in 5-HT receptor-mediated modulation of C fibre-evoked spinal field potentials are triggered by peripheral nerve injury. | Aira, Z., et al. 2010. Neuroscience. 168: 831-41. PMID: 20412834
- The opposite effect of a 5-HT1B receptor agonist on 5-HT synthesis, as well as its resistant counterpart, in an animal model of depression. | Skelin, I., et al. 2012. Brain Res Bull. 88: 477-86. PMID: 22542420
- Preclinical Evidence That 5-HT1B Receptor Agonists Show Promise as Medications for Psychostimulant Use Disorders. | Garcia, R., et al. 2017. Int J Neuropsychopharmacol. 20: 644-653. PMID: 28444326
- DIY-NAMIC Behavior: A High-Throughput Method to Measure Complex Phenotypes in the Homecage. | Lee, JH., et al. 2020. eNeuro. 7: PMID: 32561574
- Serotonin functions as a bidirectional guidance molecule regulating growth cone motility. | Vicenzi, S., et al. 2021. Cell Mol Life Sci. 78: 2247-2262. PMID: 32939562
- Systemic enhancement of serotonin signaling reverses social deficits in multiple mouse models for ASD. | Walsh, JJ., et al. 2021. Neuropsychopharmacology. 46: 2000-2010. PMID: 34239048
- Differential effects of CGS 12066B and CP-94,253 on murine social and agonistic behaviour. | Bell, R., et al. 1995. Pharmacol Biochem Behav. 52: 7-16. PMID: 7501681
Activator of:
SR-1A, SR-1B, and SR-1D.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CP 94253 hydrochloride, 10 mg | sc-203905 | 10 mg | $175.00 | |||
CP 94253 hydrochloride, 50 mg | sc-203905A | 50 mg | $681.00 |