Molecular structure of CP 93129 dihydrochloride, CAS Number: 127792-75-0
CP 93129 dihydrochloride (CAS 879089-64-2)
Alternate Names:
1,4-Dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrol[3,2-b]pyridin-5-one dihydrochloride
Application:
CP 93129 dihydrochloride is a SR-1B agonist
CAS Number:
879089-64-2
Molecular Weight:
288.18
Molecular Formula:
C12H13N3O•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CP 93129 dihydrochloride is a selective 5-HT1B agonist (Ki values are 8.1, 1100, 1500 and 7200 nM for 5-HT1B, 5-HT1D, 5-HT1A, 5-HT1C and 5-HT2, respectively).
CP 93129 dihydrochloride (CAS 879089-64-2) References
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- Extracellular serotonin in the prefrontal cortex is limited through terminal 5-HT(1B) autoreceptors: a microdialysis study in knockout mice. | de Groote, L., et al. 2002. Psychopharmacology (Berl). 162: 419-24. PMID: 12172696
- Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice. | De Groote, L., et al. 2003. Eur J Pharmacol. 476: 71-7. PMID: 12969751
- Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin. | Dölen, G., et al. 2013. Nature. 501: 179-84. PMID: 24025838
- Pharmacological and genetic identification of serotonin receptor subtypes on Drosophila larval heart and aorta. | Majeed, ZR., et al. 2014. J Comp Physiol B. 184: 205-19. PMID: 24370737
- Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster. | Majeed, ZR., et al. 2016. Neural Plast. 2016: 7291438. PMID: 26989517
- Gi-protein-coupled 5-HT1B/D receptor agonist sumatriptan induces type I hyperalgesic priming. | Araldi, D., et al. 2016. Pain. 157: 1773-1782. PMID: 27075428
- Pharmacologic assessment of bovine ruminal and mesenteric vascular serotonin receptor populations. | Snider, MA., et al. 2018. J Anim Sci. 96: 1570-1578. PMID: 29471490
- Breathing stimulation mediated by 5-HT1A and 5-HT3 receptors within the preBötzinger complex of the adult rabbit. | Iovino, L., et al. 2019. Brain Res. 1704: 26-39. PMID: 30244021
- Oxytocin-dependent reopening of a social reward learning critical period with MDMA. | Nardou, R., et al. 2019. Nature. 569: 116-120. PMID: 30944474
- Serotonin1B receptor-mediated presynaptic inhibition of proprioceptive sensory inputs to jaw-closing motoneurons. | Nagata, A., et al. 2019. Brain Res Bull. 149: 260-267. PMID: 31075304
- An injury-induced serotonergic neuron subpopulation contributes to axon regrowth and function restoration after spinal cord injury in zebrafish. | Huang, CX., et al. 2021. Nat Commun. 12: 7093. PMID: 34876587
- Serotonin-mediated increase in prefrontal cortex dopamine release: pharmacological characterization. | Iyer, RN. and Bradberry, CW. 1996. J Pharmacol Exp Ther. 277: 40-7. PMID: 8613947
- Regulation of serotonin release in the frontal cortex and ventral hippocampus of homozygous mice lacking 5-HT1B receptors: in vivo microdialysis studies. | Trillat, AC., et al. 1997. J Neurochem. 69: 2019-25. PMID: 9349547
- Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats. | Lee, MD., et al. 1998. Psychopharmacology (Berl). 136: 304-7. PMID: 9566817
Activator of:
SR-1B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CP 93129 dihydrochloride, 5 mg | sc-203904 | 5 mg | $149.00 | |||
CP 93129 dihydrochloride, 25 mg | sc-203904A | 25 mg | $630.00 |