Molecular structure of CP 775146, CAS Number: 702680-17-9
CP 775146 (CAS 702680-17-9)
Application:
CP 775146 is a high affinity and selective PPARα agonist
CAS Number:
702680-17-9
Molecular Weight:
423.54
Molecular Formula:
C26H33NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
CP 775146 is a high affinity and selective PPARα agonist.
CP 775146 (CAS 702680-17-9) References
- Molecular characterization of novel and selective peroxisome proliferator-activated receptor alpha agonists with robust hypolipidemic activity in vivo. | Kane, CD., et al. 2009. Mol Pharmacol. 75: 296-306. PMID: 18971326
- Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. | Nagiec, MM., et al. 2015. PLoS One. 10: e0120295. PMID: 25811180
- Astrocyte Elevated Gene-1 (AEG-1) Regulates Lipid Homeostasis. | Robertson, CL., et al. 2015. J Biol Chem. 290: 18227-18236. PMID: 26070567
- Lipid-sensors, enigmatic-orphan and orphan nuclear receptors as therapeutic targets in breast-cancer. | Garattini, E., et al. 2016. Oncotarget. 7: 42661-42682. PMID: 26894976
- Escherichia coli K1 Modulates Peroxisome Proliferator-Activated Receptor γ and Glucose Transporter 1 at the Blood-Brain Barrier in Neonatal Meningitis. | Krishnan, S., et al. 2016. J Infect Dis. 214: 1092-104. PMID: 27456707
- A novel role of astrocyte elevated gene-1 (AEG-1) in regulating nonalcoholic steatohepatitis (NASH). | Srivastava, J., et al. 2017. Hepatology. 66: 466-480. PMID: 28437865
- Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy. | Nogueira-Recalde, U., et al. 2019. EBioMedicine. 45: 588-605. PMID: 31285188
- Keratinocyte aquaporin-3 expression induced by histone deacetylase inhibitors is mediated in part by peroxisome proliferator-activated receptors (PPARs). | Yang, R., et al. 2020. Exp Dermatol. 29: 380-386. PMID: 32003033
- The Effects of New Selective PPARα Agonist CP775146 on Systematic Lipid Metabolism in Obese Mice and Its Potential Mechanism. | Tang, S., et al. 2020. J Diabetes Res. 2020: 4179852. PMID: 32455134
- Macrophage SR-BI modulates autophagy via VPS34 complex and PPARα transcription of Tfeb in atherosclerosis. | Tao, H., et al. 2021. J Clin Invest. 131: PMID: 33661763
- Targeting Nuclear Receptors in Neurodegeneration and Neuroinflammation. | Willems, S., et al. 2021. J Med Chem. 64: 9592-9638. PMID: 34251209
- Dissecting the Balance Between Metabolic and Oncogenic Functions of Astrocyte-Elevated Gene-1/Metadherin. | Rajesh, Y., et al. 2022. Hepatol Commun. 6: 561-575. PMID: 34741448
- Interspecies Differences in Activation of Peroxisome Proliferator-Activated Receptor γ by Pharmaceutical and Environmental Chemicals. | Garoche, C., et al. 2021. Environ Sci Technol. 55: 16489-16501. PMID: 34843233
- Transcriptomic Analysis Revealed an Important Role of Peroxisome-Proliferator-Activated Receptor Alpha Signaling in Src Homology Region 2 Domain-Containing Phosphatase-1 Insufficiency Leading to the Development of Renal Ischemia-Reperfusion Injury. | Yan, S., et al. 2022. Front Med (Lausanne). 9: 847512. PMID: 35646989
Activator of:
PPAR alpha.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CP 775146, 10 mg | sc-361158 | 10 mg | $244.00 | |||
CP 775146, 50 mg | sc-361158A | 50 mg | $999.00 |