CP 465022 hydrochlorideCAS: 199655-36-2
MF: C26H24ClFN4O•HCl
MW: 499.41
An AMPA antagonist.

CP 465022 hydrochloride (CAS 199655-36-2)

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Synonym: 3-(2-Chlorophenyl)-2-[2-[6-[(diethy lamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H) -quinazolinone hydrochloride
Application: An AMPA antagonist
CAS Number: 199655-36-2
Purity: ≥99%
Molecular Weight: 499.41
Molecular Formula: C26H24ClFN4O•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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CP 465022 hydrochloride is a selective GluR (AMPA) antagonist which is non-competitive. GluR (AMPA) is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4.


References

Lazaro et al (2002) Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist. Neuropharmacology 42 143. Menniti et al (2003) CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo. Stroke 34 171. Welch et al (2008) Traditional AMPA receptor antagonists partially block Nav1.6-mediated persistent current. Neuropharmacology 55 1165.

Physical State :
Solid
Solubility :
Soluble in water (10 mM), and DMSO (100 mM).
Storage :
Desiccate at room temperature
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
Glutamate receptor ionotropic, AMPA: IC50 = 0.1 nM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
53251536
MDL Number :
MFCD12828745
SMILES :
CCN(CC)CC1=CC=CC(=N1)/C=C/C2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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