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CP 465022 hydrochloride is a selective GluR (AMPA) antagonist which is non-competitive. GluR (AMPA) is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4.
Lazaro et al (2002) Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist. Neuropharmacology 42 143. Menniti et al (2003) CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo. Stroke 34 171. Welch et al (2008) Traditional AMPA receptor antagonists partially block Nav1.6-mediated persistent current. Neuropharmacology 55 1165.
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