Molecular structure of CNQX disodium salt, CAS Number: 479347-85-8
CNQX disodium salt (CAS 479347-85-8)
See product citations (5)
Alternate Names:
6-Cyano-7-nitroquinoxaline-2,3-dione disodium
Application:
CNQX disodium salt is a competitive kainate/quisqualate receptor antagnoist
CAS Number:
479347-85-8
Molecular Weight:
276.12
Molecular Formula:
C9H2N4O4•2Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CNQX disodium salt is a potent and competitive GluR (kainate/quisqualate (non-NMDA) receptor) antagonist. It also shows antagonism of the NMDA receptor at the glycine modulatory site. It is a more water soluble form of CNQX. In addition, it is a non-competitive antagonist of the AMPA receptor. It binds to this receptor and blocks the binding of glutamate to the AMPA receptor, thus preventing the activation of the AMPA receptor. This prevents the release of glutamate, which is an excitatory neurotransmitter, and leads to a decrease in neuronal excitation. In vitro, CNQX disodium salt may act to inhibit the activity of cAMP-dependent protein kinase A, as well as the activity of protein kinase C.
CNQX disodium salt (CAS 479347-85-8) References
- Antagonism of synaptic potentials in ventral horn neurones by 6-cyano-7-nitroquinoxaline-2,3-dione: a study in the rat spinal cord in vitro. | King, AE., et al. 1992. Br J Pharmacol. 107: 375-81. PMID: 1358390
- Glutamate receptor antagonist infused into the hypothalamic suprachiasmatic nuclei interferes with the diurnal fluctuations in plasma prolactin and corticosterone levels and injected into the mesencephalic dorsal raphe nucleus attenuates the suckling stimulus-induced release of prolactin of the rat. | Bodnár, I., et al. 2009. Brain Res Bull. 80: 9-16. PMID: 19539728
- Effect of 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate- and quisqualate-mediated depolarization of rat motoneurones in vitro. | Long, SK., et al. 1990. Br J Pharmacol. 100: 850-4. PMID: 1976402
- Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. | Watkins, JC., et al. 1990. Trends Pharmacol Sci. 11: 25-33. PMID: 2155495
- The afterhyperpolarizing potential following a train of action potentials is suppressed in an acute epilepsy model in the rat Cornu Ammonis 1 area. | Kernig, K., et al. 2012. Neuroscience. 201: 288-96. PMID: 22100272
- Comparison of nafadotride, CNQX, and haloperidol on acquisition versus expression of amphetamine-conditioned place preference in rats. | Banasikowski, TJ., et al. 2012. Behav Pharmacol. 23: 89-97. PMID: 22157177
- Photoreceptor and post-photoreceptoral contributions to photopic ERG a-wave in rhodopsin P347L transgenic rabbits. | Hirota, R., et al. 2012. Invest Ophthalmol Vis Sci. 53: 1467-72. PMID: 22273723
- NMDA or non-NMDA receptor antagonism within the amygdaloid central nucleus suppresses the affective dimension of pain in rats: evidence for hemispheric synergy. | Spuz, CA. and Borszcz, GS. 2012. J Pain. 13: 328-37. PMID: 22424916
- Stimulation within the cuneate nucleus suppresses synaptic activation of climbing fibers. | Geborek, P., et al. 2012. Front Neural Circuits. 6: 120. PMID: 23335886
- Purinergic and glutamatergic interactions in the hypothalamic paraventricular nucleus modulate sympathetic outflow. | Ferreira-Neto, HC., et al. 2013. Purinergic Signal. 9: 337-49. PMID: 23400372
- Thalamocortical relationships and network synchronization in a new genetic model 'in mirror' for absence epilepsy. | Gigout, S., et al. 2013. Brain Res. 1525: 39-52. PMID: 23743261
- The single versus combinatorial effects of MK-801, CNQX, Nifedipine and AP-3 on primary cultures of cerebellar granule cells in an oxygen-glucose deprivation model. | Zăgrean, AM., et al. 2014. Rom J Morphol Embryol. 55: 811-6. PMID: 25329107
- Excitatory orexinergic innervation of rat nucleus incertus--Implications for ascending arousal, motivation and feeding control. | Blasiak, A., et al. 2015. Neuropharmacology. 99: 432-47. PMID: 26265304
- N-oleoyldopamine modulates activity of midbrain dopaminergic neurons through multiple mechanisms. | Sergeeva, OA., et al. 2017. Neuropharmacology. 119: 111-122. PMID: 28400256
- Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. | Honoré, T., et al. 1988. Science. 241: 701-3. PMID: 2899909
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GluR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CNQX disodium salt, 1 mg | sc-203003B | 1 mg | $61.00 | |||
CNQX disodium salt, 5 mg | sc-203003 | 5 mg | $91.00 | |||
CNQX disodium salt, 10 mg | sc-203003A | 10 mg | $154.00 | |||
CNQX disodium salt, 25 mg | sc-203003C | 25 mg | $316.00 | |||
CNQX disodium salt, 50 mg | sc-203003D | 50 mg | $543.00 | |||
CNQX disodium salt, 100 mg | sc-203003E | 100 mg | $1138.00 |