Molecular structure of CP 154526 hydrochloride, CAS Number: 257639-98-8
CP 154526 hydrochloride (CAS 257639-98-8)
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Alternate Names:
N-Butyl-N-ethyl-7-mesityl-2,5-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine Hydrochloride
Application:
CP 154526 hydrochloride is a non-peptidic selectiveCRF-RI (CRF1 receptor) antagonist
CAS Number:
257639-98-8
Purity:
99%
Molecular Weight:
400.99
Molecular Formula:
C23H32N4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CP 154526 hydrochloride is a compound described to act as a selective and potent non-peptide CRF-RI (type 1 corticotropin-releasing factor CR1) receptor and ACTH (adrenocorticotropin-releasing hormone) antagonist. CRF1 belongs to the family of CRF receptors, which are involved in modifying the autonomic, behavioral, and endocrine immune response to stress. Studies report that CP 154526 blocks CRF receptors by binding with high affinity to the receptors and inhibiting the adenylate cyclase activity stimulated by CRF. CP 154526 is structurally related to Antalarmin (sc-203820).
CP 154526 hydrochloride (CAS 257639-98-8) References
- Recent advances with the CRF1 receptor: design of small molecule inhibitors, receptor subtypes and clinical indications. | McCarthy, JR., et al. 1999. Curr Pharm Des. 5: 289-315. PMID: 10213797
- Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat. | Zorrilla, EP., et al. 2002. Brain Res. 952: 188-99. PMID: 12376179
- The corticotropin-releasing factor receptor 1 antagonist CP-154,526 reverses stress-induced learning deficits in mice. | Blank, T., et al. 2003. Behav Brain Res. 138: 207-13. PMID: 12527451
- CRF1-receptor antagonist CP-154526 reduces alerting-related cutaneous vasoconstriction in conscious rabbits. | Nalivaiko, E. and Blessing, WW. 2003. Neuroscience. 117: 129-38. PMID: 12605899
- Delayed stress-induced colonic hypersensitivity in male Wistar rats: role of neurokinin-1 and corticotropin-releasing factor-1 receptors. | Schwetz, I., et al. 2004. Am J Physiol Gastrointest Liver Physiol. 286: G683-91. PMID: 14615283
- Effects of CP 154,526, a CRF1 receptor antagonist, on behavioral responses to cocaine in rats. | Przegaliński, E., et al. 2005. Neuropeptides. 39: 525-33. PMID: 16139885
- Corticotropin releasing factor-1 receptor antagonist, CP-154,526, blocks the expression of ethanol-induced behavioral sensitization in DBA/2J mice. | Fee, JR., et al. 2007. Neuroscience. 150: 14-21. PMID: 17919825
- Effects of corticotropin-releasing factor receptor-1 antagonists on the brain stress system responses to morphine withdrawal. | Navarro-Zaragoza, J., et al. 2010. Mol Pharmacol. 77: 864-73. PMID: 20159948
- Pretreatment with CP-154526 blocks the modifying effects of alarm pheromone on components of sexual behavior in male, but not in female, rats. | Kobayashi, T., et al. 2011. Chem Senses. 36: 623-32. PMID: 21502338
- Long-term loss of dopamine release mediated by CRF-1 receptors in the rat lateral septum after repeated cocaine administration. | Sotomayor-Zárate, R., et al. 2013. Behav Brain Res. 250: 206-10. PMID: 23685321
- Injection of corticotropin-releasing hormone into the amygdala aggravates visceral nociception and induces noradrenaline release in rats. | Su, J., et al. 2015. Neurogastroenterol Motil. 27: 30-9. PMID: 25359531
- Exposure to repeated immobilization stress inhibits cocaine-induced increase in dopamine extracellular levels in the rat ventral tegmental area. | Sotomayor-Zárate, R., et al. 2015. Pharmacol Res. 101: 116-23. PMID: 26318765
- Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1. | Lawrence, KM., et al. 2017. Sci Rep. 7: 5147. PMID: 28698554
- CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors. | Schulz, DW., et al. 1996. Proc Natl Acad Sci U S A. 93: 10477-82. PMID: 8816826
- A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like activity. | Lundkvist, J., et al. 1996. Eur J Pharmacol. 309: 195-200. PMID: 8874139
Inhibitor of:
ACTH, and CRF-RI.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CP 154526 hydrochloride, 10 mg | sc-205268 | 10 mg | $210.00 | |||
CP 154526 hydrochloride, 50 mg | sc-205268A | 50 mg | $860.00 |