CP-100356 Hydrochloride (CAS 142715-48-8)

CP-100356 Hydrochloride is a chemical entity that serves as a potent and selective inhibitor of the drug transporter proteins, specifically targeting the P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP), which are components of the cellular efflux mechanism responsible for pumping out foreign substances from cells. This inhibition mechanism is of particular interest in the field of pharmaceutical research, as it addresses a fundamental challenge in drug delivery, especially in overcoming multidrug resistance (MDR) in cancer cells. By inhibiting these transporter proteins, CP-100356 Hydrochloride can increase the intracellular concentration of various chemotherapeutic agents, thereby enhancing their efficacy. Its role in research extends to the study of drug-drug interactions and the optimization of pharmacokinetic profiles of therapeutic compounds, making it useful in the development of more effective treatment strategies that circumvent drug resistance mechanisms. This focus on the molecular intricacies of drug transport and resistance mechanisms highlights its importance in advancing our understanding of cellular defense systems and in the design of novel therapeutic agents.