COX4NB Antibody (2643C6a): sc-81070

COX4NB Antibody (2643C6a) is a mouse monoclonal IgG1 antibody that detects COX4NB protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-COX4NB antibody (2643C6a) is available as the non-conjugated format. COX4NB protein, also known as Neighbor of COX4, is a 210 amino acid protein encoded by COX4NB gene, located on chromosome 16. COX4NB protein is a member of the UPF0172 (NOC4) family and plays a crucial role in the assembly and function of the cytochrome c oxidase complex, an essential component of the mitochondrial respiratory chain. Proper functioning of COX4NB is vital for cellular energy production, as COX4NB facilitates the transfer of electrons and pumping of protons across the mitochondrial membrane, ultimately contributing to ATP synthesis. Disruptions in COX4NB function can lead to mitochondrial dysfunction, which is implicated in various metabolic disorders and age-related diseases. Additionally, proximity of COX4NB gene to other important genes on chromosome 16, such as those associated with giant axonal neuropathy and autoimmune disorders, highlights COX4NB′s potential significance in broader biological contexts.

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COX4NB Antibody (2643C6a) References:

1. Homozygosity mapping of giant axonal neuropathy gene to chromosome 16q24.1.  |  Ben Hamida, C., et al. 1997. Neurogenetics. 1: 129-33. PMID: 10732815
2. Novel quantitative trait loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations.  |  Karlsson, J., et al. 2003. J Immunol. 170: 1019-26. PMID: 12517969
3. Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus.  |  Forabosco, P., et al. 2006. Genes Immun. 7: 609-14. PMID: 16971955
4. Giant axonal neuropathy.  |  Yang, Y., et al. 2007. Cell Mol Life Sci. 64: 601-9. PMID: 17256086
5. Genotype-phenotype analysis in patients with giant axonal neuropathy (GAN).  |  Koop, O., et al. 2007. Neuromuscul Disord. 17: 624-30. PMID: 17587580
6. The Nodosome: Nod1 and Nod2 control bacterial infections and inflammation.  |  Tattoli, I., et al. 2007. Semin Immunopathol. 29: 289-301. PMID: 17690884
7. Identification, evolution, and association study of a novel promoter and first exon of the human NOD2 (CARD15) gene.  |  King, K., et al. 2007. Genomics. 90: 493-501. PMID: 17719742
8. High frequency of mosaic CREBBP deletions in Rubinstein-Taybi syndrome patients and mapping of somatic and germ-line breakpoints.  |  Gervasini, C., et al. 2007. Genomics. 90: 567-73. PMID: 17855048
9. Nod-like receptors in innate immunity and inflammatory diseases.  |  Carneiro, LA., et al. 2007. Ann Med. 39: 581-93. PMID: 18038361

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-COX4NB Antibody (2643C6a) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-COX4NB Antibody (2643C6a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

COX4NB Antibody (2643C6a) Specifications

Alternate Product Name: COX4NB

Product Clone Name: 2643C6a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: COX4NB

Epitope Species: human

Product Reactivity/Detection: COX4NB

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for COX4NB Antibody (2643C6a): N/A