COX4I2 Antibody (RR3): sc-100522

COX4I2 Antibody (RR3) is a mouse monoclonal IgG2a kappa light chain antibody that detects COX4I2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-COX4I2 antibody (RR3) is available as a non-conjugated format. COX4I2, also known as cytochrome c oxidase subunit 4 isoform 2, plays a critical role in cellular respiration as a component of the cytochrome c oxidase (COX) complex, which is essential for the final step of the electron transport chain. This complex facilitates the transfer of electrons from cytochrome c to molecular oxygen, leading to the formation of water and the generation of a proton gradient across the inner mitochondrial membrane, which is vital for ATP production. COX4I2 becomes particularly important under hypoxic conditions, as COX4I2 is incorporated into the COX apoenzyme to enhance activity, thereby ensuring efficient energy production when oxygen levels are low. COX4I2 is expressed in various human tissues, with highest levels found in the pancreas, and moderate levels in the heart, skeletal muscle, and placenta. Understanding COX4I2 function and regulation is crucial for elucidating the mechanisms of cellular energy metabolism and implications in various diseases, including those related to mitochondrial dysfunction.

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COX4I2 Antibody (RR3) References:

1. The 5' region of the COX4 gene contains a novel overlapping gene, NOC4.  |  Bachman, NJ., et al. 1999. Mamm Genome. 10: 506-12. PMID: 10337626
2. Mammalian subunit IV isoforms of cytochrome c oxidase.  |  Hüttemann, M., et al. 2001. Gene. 267: 111-23. PMID: 11311561
3. Differentiation-dependent repression of c-myc, B22, COX II and COX IV genes in murine erythroleukemia (MEL) cells.  |  Vizirianakis, IS., et al. 2002. Biochem Pharmacol. 63: 1009-17. PMID: 11911854
4. Rapid evolution of the human gene for cytochrome c oxidase subunit IV.  |  Lomax, MI., et al. 1992. Proc Natl Acad Sci U S A. 89: 5266-70. PMID: 1319058
5. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells.  |  Fukuda, R., et al. 2007. Cell. 129: 111-22. PMID: 17418790
6. Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1.  |  Semenza, GL. 2007. Biochem J. 405: 1-9. PMID: 17555402
7. Isolation of a cDNA clone encoding subunit IV of human cytochrome c oxidase.  |  Zeviani, M., et al. 1987. Gene. 55: 205-17. PMID: 2444497
8. The gene encoding subunit IV of cytochrome c oxidase maps to mouse chromosome 8.  |  Makris, GJ., et al. 1996. Mamm Genome. 7: 789-90. PMID: 8854875

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-COX4I2 Antibody (RR3) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-COX4I2 Antibody (RR3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

COX4I2 Antibody (RR3) Specifications

Alternate Product Name: COX4I2

Product Clone Name: RR3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 21-105

Epitope Target: COX4I2

Epitope Species: human

Product Reactivity/Detection: COX4I2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for COX4I2 Antibody (RR3): N/A