Molecular structure of COX-1 Inhibitor II, CAS Number: 304913-22-2
COX-1 Inhibitor II (CAS 304913-22-2)
Application:
COX-1 Inhibitor II is a selective inhibitor of Cox-1
CAS Number:
304913-22-2
Purity:
>95%
Molecular Weight:
296.8
Molecular Formula:
C13H13ClN2O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cox-1 Inhibitor II is a cell-permeable benzenesulfonamide compound that targets the catalytic site of Cox (cyclooxygenase). COX-1 Inhibitor II inhibits Cox-1 (IC50 of 3.2 μM) more selectively than Cox-2 (IC50 of > 100 μM). Much like Aspirin (sc-202471), COX-1 Inhibitor II has shown similar in vivo analgesic activity, yet unlike Aspirin and Indomethacin, (sc-200503) COX-1 Inhibitor II does not induce gastric disturbance. The compound was revealed to inhibit PCA response in addition to Cox-2 expression and to exert anti-inflammatory effects by suppressing phosphorylation of ERK.
COX-1 Inhibitor II (CAS 304913-22-2) References
- Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors. | Zheng, X., et al. 2007. Bioorg Med Chem. 15: 1014-21. PMID: 17079150
- Comparative protection against liver inflammation and fibrosis by a selective cyclooxygenase-2 inhibitor and a nonredox-type 5-lipoxygenase inhibitor. | Horrillo, R., et al. 2007. J Pharmacol Exp Ther. 323: 778-86. PMID: 17766677
- The COX-2 inhibitor SC-236 exerts anti-inflammatory effects by suppressing phosphorylation of ERK in a murine model. | Kim, SJ., et al. 2007. Life Sci. 81: 863-72. PMID: 17822719
Inhibitor of:
Cox-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
COX-1 Inhibitor II, 25 mg | sc-202556 | 25 mg | $195.00 |