Cox-1 Antibody (AS70): sc-52757
- Cox-1 Antibody (AS70) is a mouse monoclonal IgG1, cited in 2 publications, provided at 100 µg/ml
- recommended for detection of Cox-1 of human origin by WB and IP
- See Cox-1 (11): sc-19998 for Cox-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Cox-1 Antibody (AS70). This work is in progress.
Cox-1 Antibody (AS70) is a mouse monoclonal IgG1 antibody designed to detect Cyclooxygenase-1 (Cox-1), also known as Prostaglandin-Endoperoxide Synthase 1 (PTGS1). Cox-1 is an essential enzyme located in the endoplasmic reticulum and the nuclear envelope of cells, where Cox-1 plays a crucial role in the biosynthesis of prostaglandins from arachidonic acid. This cellular localization is vital as Cox-1 efficiently regulates the production of prostaglandins involved in maintaining normal physiological functions such as gastric mucosal protection, platelet aggregation, and renal blood flow. Unlike isozyme Cox-2, which is inducible and primarily associated with inflammatory responses, Cox-1 is constitutively expressed in most tissues, underscoring Cox-1′s importance in everyday cellular "housekeeping" activities. Anti-Cox-1 antibody (AS70) specifically recognizes human Cox-1 in applications like western blotting (WB) and immunoprecipitation (IP), ensuring reliable detection and analysis in various research settings. By targeting Cox-1, researchers can investigate Cox-1′s role in both normal physiology and in the context of diseases where prostaglandin synthesis is disrupted. Additionally, Cox-1 serves as a target for nonsteroidal anti-inflammatory drugs (NSAIDs), making Cox-1 (AS70) monoclonal antibody a valuable tool for studying drug interactions and therapeutic mechanisms. Anti-Cox-1 antibody (AS70) is an indispensable reagent for scientists exploring the intricate pathways of prostaglandin-mediated processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cox-1 Antibody (AS70) | sc-52757 | 100 µg/ml | $322.00 |