Molecular structure of Coumermycin A1, CAS Number: 4434-05-3
Coumermycin A1 (CAS 4434-05-3)
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Alternate Names:
Notomycin
Application:
Coumermycin A1 is an activator of JAK2 and Raf-1
CAS Number:
4434-05-3
Purity:
≥99%
Molecular Weight:
1110.08
Molecular Formula:
C55H59N5O20
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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SDS & Certificate of Analysis
Coumermycin A1, a cell permeable antibiotic, has been found to be a dimerizing agent that can activate a modified Raf-1 protein and stimulate the mitogen-activated protein kinase cascade. This compound has also been reported to induce autophosphorylation of GyrB-Janus Kinase (JAK) 2 fusion proteins, thus bypassing receptor activation. JAKs are cytoplasmic protein kinases that interact with intracellular domains of cytokine receptors which plays an important role in signal transduction. The activation of JAK is thought to induce cell proliferation. Studies suggest that Coumermycin A1 can inhibit the supercoiling activity of gyrase by binding to the gyrase B subunit.
Activator of:
JAK2, and Raf-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Coumermycin A1, 5 mg | sc-507271 | 5 mg | $1250.00 |