Date published: 2026-4-5

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Coumarin 6 (CAS 38215-36-0)

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Alternate Names:
Coumarin 6 is known as a fluorochrome laser dye.
Application:
Coumarin 6 is a fluorescent probe and Laser dye widely used for staining polymer particles, organelles, or other materials used in medicine.
CAS Number:
38215-36-0
Purity:
>98%
Molecular Weight:
350.43
Molecular Formula:
C20H18N2O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Coumarin 6 is a highly fluorescent probe and Laser dye, characterized by a Dye content of 98%. Its stability and exceptional performance in lifetime experiments have made it a preferred choice in fluorescence spectroscopy. This property positions Coumarin 6 as an ideal candidate for calibrating fluorescence imaging microscopy systems. Moreover, as a fluorescent probe, it holds promise for in vivo tracking, investigating cell uptake, and conducting mechanistic studies of microparticle drug delivery systems. Belonging to the 7-aminocoumarins family, Coumarin 6 acts as a fluorochrome, offering distinct optical properties for various applications. Additionally, it occurs naturally in a range of plants and herbs, including cinnamon, ginger, and cumin. The compound has been utilized for centuries in traditional medicine and is widely employed as a flavoring and fragrance ingredient in numerous food and cosmetic products. Furthermore, Coumarin 6 possesses antioxidant properties in vitro, aiding in the neutralization of reactive oxygen species. Coumarin 6 emerges as useful in various scientific fields, facilitating precise fluorescence measurements, fluorescence imaging microscopy calibration, and studies related to microparticle drug delivery systems.


Coumarin 6 (CAS 38215-36-0) References

  1. Release characteristics of polymethacrylate nanospheres containing coumarin-6.  |  Eley, JG. and Tirumalasetty, PP. 2003. J Microencapsul. 20: 653-9. PMID: 12909548
  2. Physicochemical properties affecting retinal drug/coumarin-6 delivery from nanocarrier systems via eyedrop administration.  |  Inokuchi, Y., et al. 2010. Invest Ophthalmol Vis Sci. 51: 3162-70. PMID: 20053972
  3. Coumarin 6 and 1,6-diphenyl-1,3,5-hexatriene (DPH) as fluorescent probes to monitor protein aggregation.  |  Makwana, PK., et al. 2011. Analyst. 136: 2161-7. PMID: 21445407
  4. Cellular uptake of coumarin-6 as a model drug loaded in solid lipid nanoparticles.  |  Rivolta, I., et al. 2011. J Physiol Pharmacol. 62: 45-53. PMID: 21451209
  5. Tuning the binding of coumarin 6 with DNA by molecular encapsulators: effect of β-cyclodextrin and C-hexylpyrogallol[4]arene.  |  Chandrasekaran, S., et al. 2014. J Mol Recognit. 27: 640-52. PMID: 25277088
  6. Cellular uptake of coumarin-6 under microfluidic conditions into HCE-T cells from nanoscale formulations.  |  Pretor, S., et al. 2015. Mol Pharm. 12: 34-45. PMID: 25412253
  7. Modified NLC-loaded coumarin for pharmaceutical applications: the improvement of physical stability and controlled release profile.  |  Iemsam-Arng, J., et al. 2016. Pharm Dev Technol. 21: 1015-1022. PMID: 26401882
  8. Transport Mechanism of Coumarin 6 Nanocrystals with Two Particle Sizes in MDCKII Monolayer and Larval Zebrafish.  |  Miao, X., et al. 2016. ACS Appl Mater Interfaces. 8: 12620-30. PMID: 27159431
  9. Revival of the nearly extinct fluorescence of coumarin 6 in water and complete transfer of energy to rhodamine 123.  |  Banerjee, R. and Purkayastha, P. 2017. Soft Matter. 13: 5506-5508. PMID: 28805220
  10. Transport mechanism of chitosan-N-acetylcysteine, chitosan oligosaccharides or carboxymethyl chitosan decorated coumarin-6 loaded nanostructured lipid carriers across the rabbit ocular.  |  Li, J., et al. 2017. Eur J Pharm Biopharm. 120: 89-97. PMID: 28867370
  11. Piecemeal Rekindling of Coumarin 6 Fluorescence on Stepwise Unfolding of Protein by Surfactant.  |  Banerjee, R. and Purkayastha, P. 2017. J Phys Chem B. 121: 11449-11454. PMID: 29199425
  12. Exploiting coumarin-6 as ancillary ligands in 1,10-phenanthroline Ir(iii) complexes: generating triplet photosensitisers with high upconversion capabilities.  |  Lu, Y., et al. 2018. Dalton Trans. 47: 8585-8589. PMID: 29431810
  13. Development of novel optical pH sensors based on coumarin 6 and nile blue A encapsulated in resin particles and specific support materials.  |  Duong, HD., et al. 2020. Mater Sci Eng C Mater Biol Appl. 107: 110323. PMID: 31761237
  14. FRET imaging revealed that nanocrystals enhanced drug oral absorption by dissolution rather than endocytosis: A case study of coumarin 6.  |  Zhang, G., et al. 2021. J Control Release. 332: 225-232. PMID: 33640408
  15. Self-Assembled Ru(II)-Coumarin Complexes for Selective Cell Membrane Imaging.  |  Liu, J., et al. 2022. Pharmaceutics. 14: PMID: 36365102

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Coumarin 6, 1 g

sc-217955
1 g
$92.00

Coumarin 6, 5 g

sc-217955A
5 g
$249.00

Coumarin 6, 10 g

sc-217955B
10 g
$369.00

Coumarin 6, 25 g

sc-217955C
25 g
$779.00