Molecular structure of Cotinine N-β-D-Glucuronide, CAS Number: 139427-57-9
Cotinine N-β-D-Glucuronide (CAS 139427-57-9)
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Alternate Names:
Cotinine-N-glucuronide
Application:
Cotinine N-β-D-Glucuronide is a major metabolite of Nicotine derivative
CAS Number:
139427-57-9
Molecular Weight:
352.34
Molecular Formula:
C16H20N2O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Cotinine N-β-D-Glucuronide is a glucuronide conjugate of cotinine, which itself is a primary metabolite of nicotine. The formation of glucuronide conjugates is a common biological process for increasing the water solubility of compounds, facilitating their excretion. This specific conjugation involves the attachment of glucuronic acid to the nitrogen atom of cotinine, enhancing its solubility and thus its ability to be excreted via the kidneys. Cotinine N-β-D-Glucuronide serves as a marker for studying nicotine metabolism. Its presence and concentration in biological samples can be used to understand the extent of tobacco exposure and the kinetics of nicotine metabolism.
Cotinine N-β-D-Glucuronide (CAS 139427-57-9) References
- Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10. | Kaivosaari, S., et al. 2007. Mol Pharmacol. 72: 761-8. PMID: 17576790
- A novel validated procedure for the determination of nicotine, eight nicotine metabolites and two minor tobacco alkaloids in human plasma or urine by solid-phase extraction coupled with liquid chromatography-electrospray ionization-tandem mass spectrometry. | Miller, EI., et al. 2010. J Chromatogr B Analyt Technol Biomed Life Sci. 878: 725-37. PMID: 20097626
- Development of an ultrasensitive immunochromatography test to detect nicotine metabolites in oral fluids. | Gonzalez, JM., et al. 2011. Anal Bioanal Chem. 400: 3655-64. PMID: 21556750
- Validation of a liquid chromatography-tandem mass spectrometry method for the detection of nicotine biomarkers in hair and an evaluation of wash procedures for removal of environmental nicotine. | Miller, EI., et al. 2011. J Anal Toxicol. 35: 321-32. PMID: 21740688
- Simultaneous quantification of nicotine and metabolites in rat brain by liquid chromatography-tandem mass spectrometry. | Vieira-Brock, PL., et al. 2011. J Chromatogr B Analyt Technol Biomed Life Sci. 879: 3465-74. PMID: 21963483
- Age-related differences in the disposition of nicotine and metabolites in rat brain and plasma. | Vieira-Brock, PL., et al. 2013. Nicotine Tob Res. 15: 1839-48. PMID: 23737496
- Recent Advances in Mass Spectrometry for the Identification of Neuro-chemicals and their Metabolites in Biofluids. | Kailasa, SK. and Wu, HF. 2013. Curr Neuropharmacol. 11: 436-64. PMID: 24381533
- Application of CE-MS to a metabonomics study of human urine from cigarette smokers and non-smokers. | Garcia-Perez, I., et al. 2014. Bioanalysis. 6: 2733-49. PMID: 25413705
- Simultaneous determination of nicotine and its nine metabolites in rat blood utilizing microdialysis coupled with UPLC-tandem mass spectrometry for pharmacokinetic application. | Mao, J., et al. 2015. Anal Bioanal Chem. 407: 4101-9. PMID: 25824453
- N-glucuronidation catalyzed by UGT1A4 and UGT2B10 in human liver microsomes: Assay optimization and substrate identification. | Lu, D., et al. 2017. J Pharm Biomed Anal. 145: 692-703. PMID: 28803208
- Recent Developments in the Determination of Biomarkers of Tobacco Smoke Exposure in Biological Specimens: A Review. | Marques, H., et al. 2021. Int J Environ Res Public Health. 18: PMID: 33670326
- Comprehensive metabolic study of nicotine in equine plasma and urine using liquid chromatography/high-resolution mass spectrometry for the identification of unique biomarkers for doping control. | Ishii, H., et al. 2022. J Chromatogr B Analyt Technol Biomed Life Sci. 1190: 123100. PMID: 35032890
- Identification of potential biomarkers in urine and plasma after consumption of tobacco product in horses. | Ishii, H., et al. 2022. Drug Test Anal. 14: 902-914. PMID: 35195357
- Connecting chemical exposome to human health using high-resolution mass spectrometry-based biomonitoring: Recent advances and future perspectives. | Chen, YC., et al. 2022. Mass Spectrom Rev. e21805. PMID: 36062854
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AChR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cotinine N-β-D-Glucuronide, 1 mg | sc-211139 | 1 mg | $357.00 | |||
Cotinine N-β-D-Glucuronide, 5 mg | sc-211139A | 5 mg | $1234.00 | |||
Cotinine N-β-D-Glucuronide, 10 mg | sc-211139B | 10 mg | $3198.00 |