COTI-2 (CAS 1039455-84-9)
CAS Number:
1039455-84-9
Molecular Weight:
366.48
Molecular Formula:
C19H22N6S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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COTI-2 (CAS 1039455-84-9) References
- Novel anti-cancer drug COTI-2 synergizes with therapeutic agents and does not induce resistance or exhibit cross-resistance in human cancer cell lines. | Maleki Vareki, S., et al. 2018. PLoS One. 13: e0191766. PMID: 29364966
- Role of p53 Gene in Breast Cancer: Focus on Mutation Spectrum and Therapeutic Strategies. | Kaur, RP., et al. 2018. Curr Pharm Des. 24: 3566-3575. PMID: 30255744
- COTI-2, A Novel Thiosemicarbazone Derivative, Exhibits Antitumor Activity in HNSCC through p53-dependent and -independent Mechanisms. | Lindemann, A., et al. 2019. Clin Cancer Res. 25: 5650-5662. PMID: 31308060
- COTI-2 reactivates mutant p53 and inhibits growth of triple-negative breast cancer cells. | Synnott, NC., et al. 2020. Breast Cancer Res Treat. 179: 47-56. PMID: 31538264
- COTI-2 induces cell apoptosis in pediatric acute lymphoblastic leukemia via upregulation of miR-203. | Guo, Y., et al. 2020. Bioengineered. 11: 201-208. PMID: 32063077
- Liposomal formulations of anticancer copper(II) thiosemicarbazone complexes. | Mathuber, M., et al. 2021. Dalton Trans. 50: 16053-16066. PMID: 34617075
- Restoring p53 Function in Head and Neck Squamous Cell Carcinoma to Improve Treatments. | de Bakker, T., et al. 2021. Front Oncol. 11: 799993. PMID: 35071005
- Gain of Function (GOF) Mutant p53 in Cancer-Current Therapeutic Approaches. | Roszkowska, KA., et al. 2022. Int J Mol Sci. 23: PMID: 36362074
- Therapeutic Targeting of P53: A Comparative Analysis of APR-246 and COTI-2 in Human Tumor Primary Culture 3-D Explants. | Nagourney, AJ., et al. 2023. Genes (Basel). 14: PMID: 36981018
- Degradation of MYC by the mutant p53 reactivator drug, COTI-2 in breast cancer cells. | Tang, M., et al. 2023. Invest New Drugs. 41: 541-550. PMID: 37233863
Inhibitor of:
Abp ζ, and Wip1.Activator of:
p53.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
COTI-2, 25 mg | sc-507291 | 25 mg | $310.00 |