Corynecin I (CAS 4423-58-9)

Corynecin I is an antibiotic produced by Corynebacterium spp., noted for its role in microbiological and biochemical research. The mechanism of action of Corynecin I involves inhibiting bacterial protein synthesis by binding to the bacterial ribosome, thus interfering with the translation process. This inhibition prevents the formation of essential proteins needed for bacterial growth and survival. Corynecin I has been used extensively in studies focusing on understanding the dynamics of protein synthesis and the specific interactions between antibiotics and ribosomal subunits. Researchers have employed Corynecin I to investigate bacterial resistance mechanisms, particularly how mutations in ribosomal RNA or proteins can confer resistance to antibiotics. Advanced techniques such as X-ray crystallography and cryo-electron microscopy have been utilized to explain the detailed structure of ribosomal complexes bound with Corynecin I, providing insights into its binding sites and the conformational changes induced upon binding. Additionally, Corynecin I serves as a model compound in studies aiming to design new antibiotics with improved efficacy and reduced resistance. Its role in probing the fundamental aspects of ribosome function and antibiotic resistance underscores its importance in the development of novel antimicrobial agents and the broader understanding of bacterial translation mechanisms.