Date published: 2025-10-2

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Cordycepin (CAS 73-03-0)

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Alternate Names:
3′-Deoxyadenosine
Application:
Cordycepin is an anticancer, antifungal nucleoside analog
CAS Number:
73-03-0
Purity:
≥98%
Molecular Weight:
251.24
Molecular Formula:
C10H13N5O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cordycepin, a nucleoside analog closely related to adenosine, has become a compound of significant interest in biological research due to its ability to interfere with various biochemical processes. Its primary use in research applications lies in the study of nucleic acid biosynthesis, where it is known to inhibit RNA polymerase, thereby blocking the elongation of RNA chains during transcription. This action makes it useful for scientists exploring the regulation of gene expression and the impact of RNA synthesis on cellular function. Additionally, cordycepin is used in apoptosis studies to understand its influence on programmed cell death mechanisms. Its incorporation into RNA strands can lead to premature termination, which serves as a model for investigating the effects of disrupted RNA synthesis on cell viability. Furthermore, cordycepin′s structural similarity to adenosine allows researchers to investigate its role in signal transduction pathways and energy metabolism, enhancing our grasp of cellular communication and energy dynamics.


Cordycepin (CAS 73-03-0) References

  1. Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells.  |  Kodama, EN., et al. 2000. Biochem Pharmacol. 59: 273-81. PMID: 10609556
  2. Functional study of Cordyceps sinensis and cordycepin in male reproduction: A review.  |  Chen, YC., et al. 2017. J Food Drug Anal. 25: 197-205. PMID: 28911537
  3. Cordycepin in Anticancer Research: Molecular Mechanism of Therapeutic Effects.  |  Khan, MA. and Tania, M. 2020. Curr Med Chem. 27: 983-996. PMID: 30277143
  4. Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Cordyceps Medicinal Fungus and Its Nutraceutical and Therapeutic Potential.  |  Ashraf, SA., et al. 2020. Molecules. 25: PMID: 32545666
  5. Anti-inflammatory effects of cordycepin: A review.  |  Tan, L., et al. 2020. Phytother Res.. PMID: 33090621
  6. Cordycepin Ameliorates Nonalcoholic Steatohepatitis by Activation of the AMP-Activated Protein Kinase Signaling Pathway.  |  Lan, T., et al. 2021. Hepatology. 74: 686-703. PMID: 33576035
  7. Cordycepin confers long-term neuroprotection via inhibiting neutrophil infiltration and neuroinflammation after traumatic brain injury.  |  Wei, P., et al. 2021. J Neuroinflammation. 18: 137. PMID: 34130727
  8. The Role of Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin.  |  Chen, YY., et al. 2021. Molecules. 26: PMID: 34443541
  9. A Systematic Review of the Biological Effects of Cordycepin.  |  Radhi, M., et al. 2021. Molecules. 26: PMID: 34641429
  10. Cordycepin as a Metabolite with Pharmacological Potential: A Review.  |  Sharma, S., et al. 2022. Int J Med Mushrooms. 24: 1-20. PMID: 35997091
  11. Cordycepin and kinase inhibition in cancer.  |  Khan, MA. and Tania, M. 2023. Drug Discov Today. 28: 103481. PMID: 36584876
  12. The synthesis of 3'-dATP and its use as an inhibitor of ATP-dependent DNA synthesis in toluene-treated Escherichia coli.  |  Gumport, RI. and Edelheit, EB. 1976. Biochemistry. 15: 2804-9. PMID: 779831
  13. Antifungal activity of 3'-deoxyadenosine (cordycepin).  |  Sugar, AM. and McCaffrey, RP. 1998. Antimicrob Agents Chemother. 42: 1424-7. PMID: 9624488

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cordycepin, 10 mg

sc-203902
10 mg
$99.00

What is the native source of the compound?

Asked by: two2igm05
Thank you for your question. Cordycepin (CAS 73-03-0) has a native source that is Ophiocordyceps sinensis.
Answered by: Technical Support
Date published: 2025-01-11
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Date published: 2015-04-20
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