Cord Factor (CAS 61512-20-7)
See product citations (2)
Alternate Names:
6,6′-Di-O-mycoloyl-α,α-trehalose; Trehalose 6,6-dimycolate
Application:
Cord Factor is an immunomodulatory glycolipid that induces inflammatory cytokine release independent of TLR2 or TLR4
CAS Number:
61512-20-7
Purity:
≥97%
Molecular Weight:
2,636.47
Molecular Formula:
C172O15H328
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cord Factor is a glycolipid released from mycobacterium that becomes toxic and antigenic when it interacts with cell surface lipids it possesses immunomodulatory properties. Cord Factor induces the activation of macrophages, independent of TLR2 or TLR4, to release inflammatory cytokines. It also induces thymic atrophy and granuloma formation in the lung and other organs. It is responsible for the necrosis and cavitation observed in secondary tuberculosis. Cord factors, also known as trehalose dimycolates (TDMs), are glycolipids present in the cell wall of Mycobacterium tuberculosis, the bacterium responsible for tuberculosis (TB).
Cord Factor (CAS 61512-20-7) References
- Immunological properties of trehalose dimycolate (cord factor) and other mycolic acid-containing glycolipids--a review. | Ryll, R., et al. 2001. Microbiol Immunol. 45: 801-11. PMID: 11838897
- Influence of trehalose 6,6'-dimycolate (TDM) during mycobacterial infection of bone marrow macrophages. | Indrigo, J., et al. 2002. Microbiology (Reading). 148: 1991-1998. PMID: 12101287
- 6,6'-Dimycoloyl trehalose from a rapidly growing Mycobacterium: an alternative antigen for tuberculosis serodiagnosis. | López-Marín, LM., et al. 2003. FEMS Immunol Med Microbiol. 36: 47-54. PMID: 12727365
- Mycobacterial glycolipid cord factor trehalose 6,6'-dimycolate causes a decrease in serum cortisol during the granulomatous response. | Actor, JK., et al. Neuroimmunomodulation. 10: 270-82. PMID: 12759564
- Cord factor trehalose 6,6'-dimycolate (TDM) mediates trafficking events during mycobacterial infection of murine macrophages. | Indrigo, J., et al. 2003. Microbiology (Reading). 149: 2049-2059. PMID: 12904545
- The chemical structure of the cord factor of Mycobacterium tuberculosis. | NOLL, H., et al. 1956. Biochim Biophys Acta. 20: 299-309. PMID: 13328853
- Failure of CD1D-/- mice to elicit hypersensitive granulomas to mycobacterial cord factor trehalose 6,6'-dimycolate. | Guidry, TV., et al. 2004. J Interferon Cytokine Res. 24: 362-71. PMID: 15212710
- In vivo activity of released cell wall lipids of Mycobacterium bovis bacillus Calmette-Guérin is due principally to trehalose mycolates. | Geisel, RE., et al. 2005. J Immunol. 174: 5007-15. PMID: 15814731
- Requisite role for complement C5 and the C5a receptor in granulomatous response to mycobacterial glycolipid trehalose 6,6'-dimycolate. | Borders, CW., et al. 2005. Scand J Immunol. 62: 123-30. PMID: 16101818
- Macrophage scavenger receptor down-regulates mycobacterial cord factor-induced proinflammatory cytokine production by alveolar and hepatic macrophages. | Ozeki, Y., et al. 2006. Microb Pathog. 40: 171-6. PMID: 16517114
- Interferon-gamma independent formation of pulmonary granuloma in mice by injections with trehalose dimycolate (cord factor), lipoarabinomannan and phosphatidylinositol mannosides isolated from Mycobacterium tuberculosis. | Takimoto, H., et al. 2006. Clin Exp Immunol. 144: 134-41. PMID: 16542375
- Multiple roles of cord factor in the pathogenesis of primary, secondary, and cavitary tuberculosis, including a revised description of the pathology of secondary disease. | Hunter, RL., et al. 2006. Ann Clin Lab Sci. 36: 371-86. PMID: 17127724
- Molecular and supra-molecular structure related differences in toxicity and granulomatogenic activity of mycobacterial cord factor in mice. | Fujita, Y., et al. 2007. Microb Pathog. 43: 10-21. PMID: 17434713
- Extravascular coagulation and fibrinolysis in murine lung inflammation induced by the mycobacterial cord factor trehalose-6,6'-dimycolate. | Perez, RL., et al. 1994. Am J Respir Crit Care Med. 149: 510-8. PMID: 8306054
- Development of a trehalose 6,6'-dimycolate model which explains cord formation by Mycobacterium tuberculosis. | Behling, CA., et al. 1993. Infect Immun. 61: 2296-303. PMID: 8500871
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Macrophage.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cord Factor, 1 mg | sc-202555 | 1 mg | $336.00 |