Date published: 2025-12-5

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Coproporphyrin I dihydrochloride (CAS 69477-27-6)

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Alternate Names:
3,8,13,18-Tetramethyl-21H,23H-porphine-2,7,12,17-tetrapropionic acid dihydrochloride
Application:
Coproporphyrin I dihydrochloride is a porphyrin biomarker with an absorption of λmax 395 nm
CAS Number:
69477-27-6
Purity:
≥ 85%
Molecular Weight:
727.63
Molecular Formula:
C36H38N4O82HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Coproporphyrin I dihydrochloride is a porphyrin biomarker with an absorption of lambdamax 395 nm. Biologically, it is found in excrement as a result of the breakdown of billirubin which is itself, a catabolite of heme from hemoglobin breakdown. It has implications in catalysis, inorganic chemistry, and chemical synthesis.


Coproporphyrin I dihydrochloride (CAS 69477-27-6) References

  1. Porphyrin levels in excreta of sea birds of the Chilean coasts as nondestructive biomarker of exposure to environmental pollutants.  |  Casini, S., et al. 2001. Arch Environ Contam Toxicol. 41: 65-72. PMID: 11385591
  2. Do liposome-binding constants of porphyrins correlate with their measured and predicted partitioning between octanol and water?  |  Kepczyński, M., et al. 2002. Photochem Photobiol. 76: 127-34. PMID: 12194207
  3. Isolation and Characterization of Coproporphyrin Produced by Four Subspecies of Bacillus thuringiensis.  |  Harms, RL., et al. 1986. Appl Environ Microbiol. 51: 481-6. PMID: 16347008
  4. FI automatic method for the determination of copper(II) based on coproporphyrin I-Cu(II)/TCPO/H(2)O(2) chemiluminescence reaction for the screening of waters.  |  Meseguer-Lloret, S., et al. 2004. Talanta. 64: 1030-5. PMID: 18969707
  5. Zincmethylphyrins and coproporphyrins, novel growth factors released by Sphingopyxis sp., enable laboratory cultivation of previously uncultured Leucobacter sp. through interspecies mutualism.  |  Bhuiyan, MN., et al. 2016. J Antibiot (Tokyo). 69: 97-103. PMID: 26306814
  6. Porphyrin Derivatives Inhibit the Interaction between Receptor Activator of NF-κB and Its Ligand.  |  Chypre, M., et al. 2017. ChemMedChem. 12: 1697-1702. PMID: 28885764
  7. Development of an LC-MS method to quantify coproporphyrin I and III as endogenous biomarkers for drug transporter-mediated drug-drug interactions.  |  Njumbe Ediage, E., et al. 2018. J Chromatogr B Analyt Technol Biomed Life Sci. 1073: 80-89. PMID: 29241088
  8. Rapid spectrophotometric quantification of urinary porphyrins and porphobilinogen as screening tool for attacks of acute porphyria.  |  Lang, A., et al. 2018. J Biomed Opt. 23: 1-12. PMID: 29855177
  9. Acitretin mitigates uroporphyrin-induced bone defects in congenital erythropoietic porphyria models.  |  Bragazzi Cunha, J., et al. 2021. Sci Rep. 11: 9601. PMID: 33953217
  10. Analysis of porphyrins and enzymes in porphyrin synthesis in Taenia solium cysticercus from man and pig.  |  Larralde, C., et al. 1987. Mol Biochem Parasitol. 22: 203-13. PMID: 3574346
  11. Modification of monoclonal and polyclonal IgG with palladium (II) coproporphyrin I: stimulatory and inhibitory functional effects induced by two different methods.  |  Martsev, SP., et al. 1995. J Immunol Methods. 186: 293-304. PMID: 7594629
  12. Separation of porphyrins by capillary electrophoresis in fused-silica and ethylene vinyl acetate copolymer capillaries with visible absorbance detection.  |  Chiang, SC. and Li, SF. 1997. Biomed Chromatogr. 11: 366-70. PMID: 9413617
  13. Specific Interaction of Coproporphyrin I with Antibodies in Water and Reverse Micelles: Dimerization of Antibodies Affects Antigen Binding Site  |  Evgenia G. Matveeva, Marina I. Nelen, Oleg I. Lobanov & Alexander P. Savitsky. 2003. Journal of Fluorescence volume. 13: 79–88.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Coproporphyrin I dihydrochloride, 25 mg

sc-234416
25 mg
$118.00

Coproporphyrin I dihydrochloride, 100 mg

sc-234416A
100 mg
$385.00