Date published: 2025-10-31

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Copper diethyldithiocarbamate (CAS 13681-87-3)

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Alternate Names:
Diethyldithiocarbamic Acid Copper Salt
CAS Number:
13681-87-3
Molecular Weight:
360.07
Molecular Formula:
C10H20CuN2S4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Copper diethyldithiocarbamate (CuDDC) holds a prominent position as an industrial chemical compound widely utilized in diverse applications. It serves as both a chelating agent and a complexing agent, finding utility in water treatment, metal plating, and oil production. The extensive exploration of Copper diethyldithiocarbamate has shed light on its multifaceted biochemical and physiological effects, as well as its potential contributions to scientific research. Copper diethyldithiocarbamate has been the subject of thorough investigation due to its prospective applications in scientific research. Notably, it has demonstrated its efficacy as a chelating agent in a range of biochemical experiments involving metals, proteins, and enzymes. Furthermore, Copper diethyldithiocarbamate has been employed as a complexing agent in synthesizing diverse organic compounds, including heterocyclic compounds, and as a reagent in protein purification. The chelating properties of Copper diethyldithiocarbamate arise from its ability to form a complex with metal ions, thereby impeding the participation of the metal ions in subsequent reactions. As a complexing agent, Copper diethyldithiocarbamate facilitates the formation of complexes with organic compounds, thereby enabling their isolation and purification.


Copper diethyldithiocarbamate (CAS 13681-87-3) References

  1. [Activation of cellular defense mechanism by organic-inorganic hybrid molecules].  |  Fujie, T., et al. 2014. Yakugaku Zasshi. 134: 813-5. PMID: 24989472
  2. Copper diethyldithiocarbamate as an activator of Nrf2 in cultured vascular endothelial cells.  |  Fujie, T., et al. 2016. J Biol Inorg Chem. 21: 263-73. PMID: 26825804
  3. Induction of metallothionein isoforms by copper diethyldithiocarbamate in cultured vascular endothelial cells.  |  Fujie, T., et al. 2016. J Toxicol Sci. 41: 225-32. PMID: 26961606
  4. Development and optimization of an injectable formulation of copper diethyldithiocarbamate, an active anticancer agent.  |  Wehbe, M., et al. 2017. Int J Nanomedicine. 12: 4129-4146. PMID: 28615941
  5. Copper diethyldithiocarbamate as an inhibitor of tissue plasminogen activator synthesis in cultured human coronary endothelial cells.  |  Fujie, T., et al. 2017. J Toxicol Sci. 42: 553-558. PMID: 28904290
  6. Disulfiram Copper Nanoparticles Prepared with a Stabilized Metal Ion Ligand Complex Method for Treating Drug-Resistant Prostate Cancers.  |  Chen, W., et al. 2018. ACS Appl Mater Interfaces. 10: 41118-41128. PMID: 30444340
  7. Doxorubicin intercalated copper diethyldithiocarbamate functionalized layered double hydroxide hybrid nanoparticles for targeted therapy of hepatocellular carcinoma.  |  Xu, Y., et al. 2020. Biomater Sci. 8: 897-911. PMID: 31825410
  8. Transcriptional Induction of Cystathionine γ-Lyase, a Reactive Sulfur-Producing Enzyme, by Copper Diethyldithiocarbamate in Cultured Vascular Endothelial Cells.  |  Fujie, T., et al. 2020. Int J Mol Sci. 21: PMID: 32842680
  9. Novel nanoformulated diethyldithiocarbamate complexes with biosynthesized or green chemosynthesized copper oxide nanoparticles: An in vitro comparative anticancer study.  |  Abu-Serie, MM. and Eltarahony, M. 2021. Int J Pharm. 609: 121149. PMID: 34601057
  10. One-Step Synthesis of Nanoliposomal Copper Diethyldithiocarbamate and Its Assessment for Cancer Therapy.  |  Paun, RA., et al. 2022. Pharmaceutics. 14: PMID: 35336014
  11. Diethyldithiocarbamate copper nanoparticle overcomes resistance in cancer therapy without inhibiting P-glycoprotein.  |  Kang, X., et al. 2023. Nanomedicine. 47: 102620. PMID: 36265559
  12. The treatment of hepatocellular carcinoma with SP94 modified asymmetrical bilayer lipid-encapsulated Cu(DDC)2 nanoparticles facilitating Cu accumulation in the tumor.  |  Liu, H., et al. 2023. Expert Opin Drug Deliv. 20: 145-158. PMID: 36462209
  13. Sonoprinting nanoparticles on cellular spheroids via surface acoustic waves for enhanced nanotherapeutics delivery.  |  Rasouli, R., et al. 2023. Lab Chip. 23: 2091-2105. PMID: 36942710

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Copper diethyldithiocarbamate, 25 g

sc-486269
25 g
$218.00