Molecular structure of Convulxin, CAS Number: 37206-04-5
Convulxin (CAS 37206-04-5)
See product citations (32)
Alternate Names:
Convulxin also known as Factor X Activator-RVV
Application:
Convulxin is a heterodimeric C-type lectin shown to activate mammalian platelets and can induce platelet prothrombinase activity
CAS Number:
37206-04-5
Purity:
>90%
Molecular Weight:
~84 kDa
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Convulxin is a 72-kDa glycoprotein and a member of the heterodimeric C-type lectin family. Convulxin acts as a potent platelet activator and has been described to induce platelet prothrombinase activity. Data suggests that Convulxin induces the collagen signaling pathway to activate platelets by interacting with the p62/GPV receptor. Convulxin activates collagen receptor glycoprotein VI (GPVI) on platelets and initiates blood clotting. Additional studies suggest that Convulxin has the ability to enhance the tryosine phosphorylation of the platelet endothelial cell adhesion molecule-1 (CD31), and binds to native GPIb and GPVI.
Convulxin (CAS 37206-04-5) References
- Surface expression and functional characterization of alpha-granule factor V in human platelets: effects of ionophore A23187, thrombin, collagen, and convulxin. | Alberio, L., et al. 2000. Blood. 95: 1694-702. PMID: 10688826
- Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases. | Cicmil, M., et al. 2000. J Biol Chem. 275: 27339-47. PMID: 10858437
- Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin. | Asazuma, N., et al. 2000. J Biol Chem. 275: 33427-34. PMID: 10942756
- Expression of the platelet receptor GPVI confers signaling via the Fc receptor gamma -chain in response to the snake venom convulxin but not to collagen. | Zheng, YM., et al. 2001. J Biol Chem. 276: 12999-3006. PMID: 11152687
- Signalling events underlying platelet aggregation induced by the glycoprotein VI agonist convulxin. | Atkinson, BT., et al. 2001. Eur J Biochem. 268: 5242-8. PMID: 11606185
- The Fc receptor gamma-chain is necessary and sufficient to initiate signalling through glycoprotein VI in transfected cells by the snake C-type lectin, convulxin. | Berlanga, O., et al. 2002. Eur J Biochem. 269: 2951-60. PMID: 12071959
- Convulxin binds to native, human glycoprotein Ib alpha. | Kanaji, S., et al. 2003. J Biol Chem. 278: 39452-60. PMID: 12881531
- Crystal structure of the platelet activator convulxin, a disulfide-linked alpha4beta4 cyclic tetramer from the venom of Crotalus durissus terrificus. | Murakami, MT., et al. 2003. Biochem Biophys Res Commun. 310: 478-82. PMID: 14521935
- Structure of the snake-venom toxin convulxin. | Batuwangala, T., et al. 2004. Acta Crystallogr D Biol Crystallogr. 60: 46-53. PMID: 14684891
- Convulxin-induced platelet adhesion and aggregation: involvement of glycoproteins VI and IaIIa. | Jandrot-Perrus, M., et al. 1998. Platelets. 9: 207-11. PMID: 16793703
- Inflammasome NLRP3 activation induced by Convulxin, a C-type lectin-like isolated from Crotalus durissus terrificus snake venom. | Rego, CMA., et al. 2022. Sci Rep. 12: 4706. PMID: 35304541
- Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor. | Polgár, J., et al. 1997. J Biol Chem. 272: 13576-83. PMID: 9153205
- Convulxin, a potent platelet-aggregating protein from Crotalus durissus terrificus venom, specifically binds to platelets. | Francischetti, IM., et al. 1997. Toxicon. 35: 1217-28. PMID: 9278971
- Adhesion and activation of human platelets induced by convulxin involve glycoprotein VI and integrin alpha2beta1. | Jandrot-Perrus, M., et al. 1997. J Biol Chem. 272: 27035-41. PMID: 9341142
Activator of:
PF-4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Convulxin, 50 µg | sc-202554 | 50 µg | $832.00 | |||
| US: Only available in the US | ||||||