connexin 30.3 Antibody (F6): sc-81802

Connexin 30.3 Antibody (F6) is a mouse monoclonal IgG2a kappa light chain antibody that detects connexin 30.3 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-connexin 30.3 antibody (F6) is available as a non-conjugated format. Connexin 30.3 protein, also known as GJB4 or gap junction beta-4 protein, is primarily located in the epidermis, specifically in the upper spinous and granular layers, where GJB4 plays a crucial role in keratinocyte intercellular communication. This communication is vital for maintaining skin homeostasis and facilitating the exchange of ions and small molecules, which is essential for cellular signaling and tissue repair. Disruptions in connexin 30.3 function due to genetic mutations can lead to conditions such as erythrokeratodermia variabilis, characterized by hyperkeratosis and transient erythematous patches, highlighting GJB4′s importance in skin health. With an ability to form hexameric complexes known as connexons, connexin 30.3 contributes to the formation of gap junctions that allow for direct intercellular communication, making GJB4 a significant target for research in dermatological and cellular biology studies.

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connexin 30.3 Antibody (F6) References:

1. Mutation in the gene for connexin 30.3 in a family with erythrokeratodermia variabilis.  |  Macari, F., et al. 2000. Am J Hum Genet. 67: 1296-301. PMID: 11017804
2. Emerging issues of connexin channels: biophysics fills the gap.  |  Harris, AL. 2001. Q Rev Biophys. 34: 325-472. PMID: 11838236
3. Genetic heterogeneity in erythrokeratodermia variabilis: novel mutations in the connexin gene GJB4 (Cx30.3) and genotype-phenotype correlations.  |  Richard, G., et al. 2003. J Invest Dermatol. 120: 601-9. PMID: 12648223
4. Erythrokeratoderma variabilis without connexin 31 or connexin 30.3 gene mutation: immunohistological, ultrastructural and genetic studies.  |  Arita, K., et al. 2003. Acta Derm Venereol. 83: 266-70. PMID: 12926797
5. Molecular interaction of connexin 30.3 and connexin 31 suggests a dominant-negative mechanism associated with erythrokeratodermia variabilis.  |  Plantard, L., et al. 2003. Hum Mol Genet. 12: 3287-94. PMID: 14583444
6. Characterization of connexin 30.3 and 43 in thymocytes.  |  Fonseca, PC., et al. 2004. Immunol Lett. 94: 65-75. PMID: 15234537
7. A case of erythrokeratoderma variabilis: loosened gap junctions in the acanthotic epidermis.  |  Tamaki, Y., et al. 2006. J Dermatol. 33: 419-23. PMID: 16700834
8. Characterization of connexin30.3-deficient mice suggests a possible role of connexin30.3 in olfaction.  |  Zheng-Fischhöfer, Q., et al. 2007. Eur J Cell Biol. 86: 683-700. PMID: 17728008
9. Human cardiac gap junctions: isolation, ultrastructure, and protein composition.  |  Manjunath, CK., et al. 1987. J Mol Cell Cardiol. 19: 131-4. PMID: 3573042

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-connexin 30.3 Antibody (F6) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-connexin 30.3 Antibody (F6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

connexin 30.3 Antibody (F6) Specifications

Alternate Product Name: GJB4

Product Clone Name: F6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-267

Epitope Target: connexin 30.3

Epitope Species: human

Product Reactivity/Detection: connexin 30.3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for connexin 30.3 Antibody (F6): N/A