connexin 26 Antibody (1C6): sc-293223

Connexin 26 Antibody (1C6) is a mouse monoclonal IgG2b kappa light chain antibody that detects connexin 26 protein, also known as GJB2, in human samples through western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-connexin 26 antibody (1C6) is offered as a non-conjugated format, specifically designed to facilitate the study of gap junction communication in human tissues. Connexin 26 (1C6) monoclonal antibody plays a crucial role in studying gap junctions, which are essential for intercellular communication, allowing the transfer of ions and small molecules between adjacent cells. This function is particularly important in maintaining homeostasis in various tissues, including the cochlea of the inner ear, where connexin 26 is vital for auditory function. Mutations in the GJB2 gene, which encodes connexin 26, are linked to approximately half of the cases of autosomal recessive non-syndromic hearing loss, highlighting connexin 26′s significance in sensory biology. The ability of connexin proteins to form distinct channels with varying permeabilities underscores the complexity of cellular communication and its implications in health and disease. Anti-connexin 26 antibody (1C6) enables researchers to gain insights into the molecular mechanisms underlying hearing loss and other conditions associated with impaired gap junction function.

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connexin 26 Antibody (1C6) References:

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