Molecular structure of COMU, CAS Number: 1075198-30-9
COMU (CAS 1075198-30-9)
Alternate Names:
1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholinocarbenium hexafluorophosphate
CAS Number:
1075198-30-9
Molecular Weight:
428.27
Molecular Formula:
C12H19F6N4O4P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
COMU, a recently developed synthetic compound, is derived from Urea, a naturally occurring compound. COMU has found utility in a multitude of scientific research applications, encompassing the investigation of cellular processes and biochemical pathways. Its versatility extends to the assessment of compound effects on enzyme and protein activity, as well as the study of cellular stress. The mechanism of action employed by COMU involves inhibiting enzymes and proteins, effectively impeding their activity. This inhibition is attributed to COMU′s capability to bind to the active site of the enzyme or protein, thwarting substrate binding and subsequent functionality.
COMU (CAS 1075198-30-9) References
- COMU: a safer and more effective replacement for benzotriazole-based uronium coupling reagents. | El-Faham, A., et al. 2009. Chemistry. 15: 9404-16. PMID: 19621394
- COMU: a third generation of uronium-type coupling reagents. | El-Faham, A. and Albericio, F. 2010. J Pept Sci. 16: 6-9. PMID: 19950108
- Efficient and versatile COMU-mediated solid-phase submonomer synthesis of arylopeptoids (oligomeric N-substituted aminomethyl benzamides). | Hjelmgaard, T., et al. 2011. Org Biomol Chem. 9: 6832-43. PMID: 21837337
- Evaluation of COMU as a coupling reagent for in situ neutralization Boc solid phase peptide synthesis. | Hjørringgaard, CU., et al. 2012. J Pept Sci. 18: 199-207. PMID: 22252935
- Epimerization free synthesis of O-acyl isodipeptides employing COMU. | Samarasimhareddy, M., et al. 2012. Protein Pept Lett. 19: 406-10. PMID: 22462499
- COMU: scope and limitations of the latest innovation in peptide acyl transfer reagents. | Subirós-Funosas, R., et al. 2013. J Pept Sci. 19: 408-14. PMID: 23712932
- TOMBU and COMBU as Novel Uronium-type peptide coupling reagents derived from Oxyma-B. | Jad, YE., et al. 2014. Molecules. 19: 18953-65. PMID: 25412042
- Re-evaluating the stability of COMU in different solvents. | Kumar, A., et al. 2017. J Pept Sci. 23: 763-768. PMID: 28681413
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
COMU, 5 g | sc-223897 | 5 g | $48.00 | |||
COMU, 25 g | sc-223897A | 25 g | $284.00 |